Week-1:
Lecture-1- Introduction to soft ionisation mass spectrometry--ESI-MS and MALDI-MS
Lecture-2- Isotopic distribution of signals in mass spectra-and-deconvolution of mass spectra
Lecture-3- Resolution of mass spectra and accuracy of mass measurement and introduction of molecular medicine
Lecture-4- Mass spectra of human hemoglobin and glycated hemoglobin as a diabetes marker glutathionyl hemoglobin as oxidative stress marker
Lecture-5- Mass spectrometry based quantification of oxidative stress in patients with chronic renal failure
Week-2:
Lecture-6- Introduction to tandem mass spectrometry and principle of de novo sequencing
Lecture-7- Chemical modification and enzyme digestion of a peptide-a step towards de novo sequencing
Lecture-8- De novo sequencing of a peptide from chemical derivatization and tandem mass spectra
Lecture-9- De novo sequencing--identification of isobaric amino acid and disulfide connectivity
Lecture-10- De novo sequencing of a tryptic peptide from tandem mass spectra
Week-3:
Lecture-11- De novo sequencing from tandem-MS and SPITC derivatization to simplify tandem-MS
Lecture-12- Routine diagnosis of Hemoglobinopathy--A disease caused by genetic variant of hemoglobin
Lecture-13- Hemoglobinopathies--Identification and characterisation using bottom up proteomics approach--Part-1
Lecture-14- Hemoglobinopathies--Identification and characterisation using bottom up proteomics approach--Part-2
Lecture-15- A genetic variant of hemoglobin causing false elevation of HbA1c and hence false diagnosis of diabetes mellitus
Week-4:
Lecture-16- Nano-LC-ESI-MS based analysis of a proteome - A bottom up proteomics approach
Lecture-17- Iron salts as food fortificants to combat Iron Deficiency Anemia
Lecture-18- Nano ferric pyrophosphate as a food fortificant in a rat model--Bioavailability and toxicity assessment
Lecture-19- Nano ferric pyrophosphate as a food fortificant in rat model--Toxicity assessment using biochemical histopathological and proteomics approach
Lecture-20- Nano ferric pyrophosphate as a food fortificant in a rat model--Exploring biomarker of toxicity using plasma proteomics
Week-5:
Lecture-21- Biomarker for nano particles induced toxicity in a rat model---nLC-ESI-MS based plasma proteomics approach
Lecture-22- Quantitative proteomics of rat plasma proteins---Absolute quantification of Fetuin B--a biomarker of nano particle toxicity
Lecture-23- 2D-gel-electrophoresis based proteomics-principle and methods
Lecture-24- Differential plasma proteomics--2D-gel based approach
Lecture-25- Analysis of 2D gel spots-in-gel digestion-identification of proteins-- MALDI-MS based approach
Week-6:
Lecture-26- Mass spectrometry based absolute quantification of human plasma proteins
Lecture-27- Absolute quantification of plasma Apolipoprotein-AIV-A probable biomarker of attempted suicide
Lecture-28- MALDI-MS based identification of microorganism in clinical samples
Lecture-29- Native mass spectrometry using nano-ESI-MS platform
Lecture-30- Analysis of an array of glycated hemoglobin in patients with poorly controlled diabetes mellitus
Week-7:
Lecture-31- Molecular mechanism of sickle hemoglobin polymerisation
Lecture-32- Inhibition of sickle hemoglobin polymerisation upon glutathionylation
Lecture-33- Structural analysis of desorbed hemoglobin from nano particle surface
Lecture-34- Functional assay of human hemoglobin and its variants
Lecture-35- Application of native mass spectrometry to calculate equilibrium constant
Week-8:
Lecture-36- Bioconjugation of para-benzoquinone-of-cigarette-smoke-and-human-hemoglobin
Lecture-37- Bioconjugation of human hemoglobin with quinone as airborne environment pollutants
Lecture-38- ion mobility-mass-spectrometry
Lecture-39- Introduction-to-hydrogen-deuterium-exchange mass spectrometry
Lecture-40- Rate law of hydrogen-deuterium-exchange kinetics
Week-9:
Lecture-41- Molecular insights in inhibition of HbS polymerisation upon oxygenation monitored by HDX-MS platform-part-I
Lecture-42- Molecular insights in inhibition of HbS polymerisation upon oxygenation monitored by HDX-MS platform-part-II
Lecture-43- Molecular insights in inhibition of HbS polymerisation upon oxygenation -part-III- and upon glutathionylation-part-I-monitored by HDX-MS platform
Lecture-44- Molecular insights in inhibition of HbS polymerisation upon glutathionylation-part-II-monitored by HDX-MS platform
Lecture-45- N-acetyl cysteine as an antisickling agent in sickle cell disease
Week-10:
Lecture-46- Effect of quinones on morphology of human RBC
Lecture-47- Effect-of-NAC-to neutralise-quinone-and-in-vivo-HDX
Lecture-48- Application of HDX-MS in structural analysis of hemoglobin in vivo
Lecture-49- Application of HDX-MS in structural analysis of hemoglobin in vivo-and-desorbed-hemoglobin from nano particle-surface
Lecture-50- Application-of-HDX-MS-and -CD-spectroscopy-to-monitor-structural changes-of hemoglobin from NP surface
Week-11:
Lecture-51- Structure-function correlation of Hb Beckman, a genetic variant of human hemoglobin, using HDX-MS
Lecture-52- Structure-function correlation of glutathionyl hemoglobin, a posttranslational variant of human hemoglobin, using HDX-MS
Lecture-53- Fundamentals of tissue imaging mass spectrometry using MALDI-MS
Lecture-54- Kidney tissue imaging in a nano particle exposed rat model
Lecture-55- Imaging of kidney tissues of NP exposed rats and imaging of human prostate tissue
Week-12:
Lecture-56- Imaging of human prostate cancer tissue using MALDI-MS
Lecture-57- Imaging of human prostate cancer tissue using MALDI-MS and analysis of tissue proteomics data
Lecture-58- Desorption Electrospray Ionisation based Mass Spectrometric Imaging of Prostate Cancer Tissue
Lecture-59- Fast photochemical oxidation of protein combined to mass spectrometry for protein footprinting both in vitro and in vivo
Lecture-60- Biosimilar-monitored through mass spectrometric techniques
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