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Interpretative molecular spectroscopy

By Prof. M. S. Balakrishna   |   IIT Bombay
Learners enrolled: 288   |  Exam registration: 4
ABOUT THE COURSE:
The objective of the course, “Interpretative Molecular Spectroscopy” is to make the students familiar with important spectroscopic methods such as, NMR, UV-visible, IR and mass spectrometry to analyze and interpret the data without any ambiguity. This course elaborates on multinuclear NMR and how effectively one can use the data to assess the reactivity and also to get information about the reaction mechanism. Simple method is used to teach the interpretation of spectral data by choosing numerous examples taken from research articles and also from our own research group. This course is very useful for Synthetic Chemists in Research and Industries, Biological Chemists, Natural Product Chemists, Forensic Chemists and also Environmental Chemists and BSc/MSc/PhD students.

INTENDED AUDIENCE: Students studying BSc/MSc/PhD and Biotechnology, chemists working in chemical industries/R&D units.

PREREQUISITES: Even students with 12th grade knowledge can take this. Those who are studying BSc, MSc and also PhD students can take this.

INDUSTRY SUPPORT: This course comes very handy to those who work in chemical/pharmaceutical industries.
Summary
Course Status : Upcoming
Course Type : Core
Language for course content : English
Duration : 12 weeks
Category :
  • Chemistry
Credit Points : 3
Level : Undergraduate/Postgraduate
Start Date : 20 Jan 2025
End Date : 11 Apr 2025
Enrollment Ends : 27 Jan 2025
Exam Registration Ends : 14 Feb 2025
Exam Date : 27 Apr 2025 IST

Note: This exam date is subject to change based on seat availability. You can check final exam date on your hall ticket.


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Course layout

Week 1:  Lectures 1 to 5: Introduction to spectroscopy, different types of spectroscopic methods, General Process for Structure Elucidation of an Unknown, Spectral Interpretation, brief discussion on all spectroscopic and analytical methods.

Week 2: Lectures 6 – 10: Introduction to NMR, Basic aspects, nuclear spin, magnetic field, shielding, NMR signals, NMR spectrometer, Proton NMR, NMR spectra of simple molecules, chemical shifts, coupling constants etc.

Week 3: Lectures 10 – 15: 1H NMR: 1H NMR spectra of organic, inorganic and organometallic compounds, different types of couplings. Compounds with other NMR active nuclei such as 11B, 19F, 31P and their interactions and couplings. Analysis and interpretation of numerous examples.

Week 4: Lectures 15 – 20: 13CNMR, brief introduction, interpretation of 13C NMR spectra. 31P NMR, brief introduction. Interpretation and analysis of 31P NMR spectra of phosphorus compounds, phosphines, coordination compounds and organometallic compounds containing organophosphorus ligands.

Week 5: Lectures 20 – 25: Studying reaction mechanisms using 1H and 31P NMR spectral data. Complex spectra containing several NMR active nuclei and understanding the splitting patterns.

Week 6: Lectures 25 – 30: Multinuclear NMR, Discussion on various NMR active nuclei other than 1H, 13C and 31P. NMR spectra of compounds containing lithium, boron, silicon, selenium, tungsten, rhodium and platinum.

Week 7: Lectures 30 – 35: UV-visible spectroscopy: microstates, term symbols, determining ground term. Selection rules, Spin-orbit coupling, classification of d-d transitions. Orgel diagram, TS-diagram. Charge transfer transitions.

Week 8: Lectures 35 – 40: Interpretation of electronic spectra of coordination compounds, d1— d9 system. Examples for each system. Application of UV-visible spectroscopy in understanding inorganic reaction mechanism.

Week 9: Lectures 40 – 45: IR spectroscopy, Brief introduction, Interpretation of IR spectra of inorganic, organic and organometallic compounds. Summary.

Week 10: Lectures 45 – 50: IR spectroscopy continued with more examples: Elucidation of structures using a combination of NMR, UV-visible and IR spectral data. Examples of inorganic, organic and organometallic compounds.

Week 11: Lectures 50 – 55: Mass spectrometry: Brief introduction, fundamentals of mass spectrometry. Different methods, Data interpretation. Examples of inorganic, organic and organometallic compounds.

Week 12: Lectures 55 – 60: Other applications and summarizing all spectroscopic methods.

Books and references

Inorganic Chemistry, 3rd Edition, 1999, D. F. Shriver, P. W. Atkins, Oxford University Press, Oxford.
Inorg. Chemistry 2nd, 3rd or 4th Edition, C. E. Housecroft and A. G. sharpe, Pearson, Prentice Hall.
Nuclear Magnetic Resonance, W. W. Paudler, John Wiley & Sons, 1987.
Introduction to Multinuclear NMR, C. H. Yoder and C. D. Schaeffer Jr., Benzamin/Cummings, Pub. Co. 1987
Organic Spectroscopy, 3rd Ed. W. Kemp.
Phosphorus-31 NMR spectroscopy, Olaf Kuhl, Springer 2008.

Instructor bio

Prof. M. S. Balakrishna

IIT Bombay
Prof. M.S. Balkrishna Joined the department of chemistry in 1996. Taught Transition metal chemistry, coordination chemistry, interpretative molecular spectroscopy, organometallic chemistry of main group elements to UG, PG and Ph.D. scholars. Research interests: Main group and transition metal chemistry, organophosphorus chemistry, homogeneous catalysis and biological applications of copper(I) complexes. Published 210 research papers, five book chapters, edited a book on copper(I) complexes of phosphines (Elsevier) and has delivered more than 500 invited lectures. Balakrishna has supervised 23 PhD students, several M.Sc. students and postdoctoral fellows.

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 27 April 2025 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score
 
Please note that assignments encompass all types (including quizzes, programming tasks, and essay submissions) available in the specific week.

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Bombay .It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team


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