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Computational Quantum Chemistry

By Prof. Achintya Kumar Dutta   |   IIT Bombay
Learners enrolled: 999   |  Exam registration: 75
ABOUT THE COURSE:
Computational chemistry is one of the major branches of modern chemistry. This course is designed for those interested in learning how to simulate the chemical properties of atoms, molecules, and clusters using the popular and free quantum chemistry software package ORCA. It will cover both the theoretical and practical aspects of computational chemistry. Students will learn how to prepare input files, submit calculations, and interpret the results. The course will be beneficial for both theoretical and experimental chemists and biologists.

INTENDED AUDIENCE: Senior Bachelor, Master and Ph.D. students

PREREQUISITES: Quantum Chemistry of Atoms and Molecules - https://nptel.ac.in/courses/104101124

INDUSTRY SUPPORT: Any company that has R&D department in chemistry, biology, and drug discovery
Summary
Course Status : Ongoing
Course Type : Elective
Language for course content : English
Duration : 12 weeks
Category :
  • Chemistry
  • Metallurgy and Material science & Mining Engineering
  • Computational Biology
Credit Points : 3
Level : Undergraduate/Postgraduate
Start Date : 20 Jan 2025
End Date : 11 Apr 2025
Enrollment Ends : 03 Feb 2025
Exam Registration Ends : 28 Feb 2025
Exam Date : 26 Apr 2025 IST

Note: This exam date is subject to change based on seat availability. You can check final exam date on your hall ticket.


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Course layout

Week 1: 
Lecture 1 : Why computational chemistry?
Lecture 2 : Recapitulation of the basics of quantum mechanics and introduction to ORCA program package
Lecture 3 : Installing ORCA and running your first calculations 

Week 2: 
Lecture 4: Hartree-Fock Approximation and Basis Set
Lecture 5: Open-Shell Systems and Spin
Lecture 6: Installing Avogadro, Visualization of orbital and population 

Week 3: 
Lecture 7: Electron Correlation, MP2 and Coupled Cluster
Lecture 8: Lower scaling approximation
Lecture 9: Localized orbital based method  

Week 4: 
Lecture 10: Geometry Optimization
Lecture 11: Finding transition states
Lecture 12: Conformational search and surface scan  

Week 5: 
Lecture 13. Density Functional Theory
Lecture 14: Various DFT functional and converging difficult calculations
Lecture 15: Conceptual DFT and Reactivity  

Week 6: 
Lecture 16: Semi-empirical methods
Lecture 17: Environmental Effect, implicit and explicit solvation
Lecture 18: Relativistic effect and spin-orbit coupling
 
Week 7: 
Lecture 19: Basis set incompleteness error and counterpoise correction
Lecture 20: Vibrational spectroscopy, IR, and Raman spectra
Lecture 21: Visualization of vibrational modes 

Week 8: 
Lecture 22: Excited State and UV-Vis Spectroscopy
Lecture 23: Visualizing excited state, difference density, and natural transition orbital
Lecture 24: X-ray spectroscopy  

Week 9: 
Lecture 25: Electronic Circular Dichroism Spectroscopy
Lecture 26: NMR spectroscopy
Lecture 27: Predicting EPR 

Week 10: 
Lecture 28: Molecular Mechanism
Lecture 29: Molecular Dynamics Simulation
Lecture 30: Multiscale-Simulation QM/MM 

Week 11: 
Lecture 31: Multi-reference method CASSCF:
Lecture 32: Choosing an appropriate active space
Lecture 33: Perturbational and CI correction

Week 12: 
Lecture 34: Energy decomposition analysis
Lecture 35: Beyond Born-Oppenheimer approximations
Lecture 36: Understanding the pitfalls of the calculations 

Books and references

  1. Frank Jensen, Introduction to Computational Chemistry, 3rd Edition, Willey 2017.
  2. Christopher J. Cramer, Essentials of Computational Chemistry: Theories and Models, 2nd Edition, Willey 2004.
  3. Trygve Helgaker, Poul Jørgensen, Jeppe Olsen Molecular Electronic‐Structure Theory, Willey 2000.
  4. https://orcaforum.kofo.mpg.de/app.php/portal

Instructor bio

Prof. Achintya Kumar Dutta

IIT Bombay
Prof. Achintya Kumar Dutta is an associate Professor in the department of Chemistry at IIT Bombay. His primary research interest is on development of lower scaling wave-function based methods within the domain of relativistic quantum chemistry. He has published 54 papers to date and lead authors of the quantum chemistry software package ORCA and BAGH.

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: EXAM DATE : April 26, 2025 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

Please note that assignments encompass all types (including quizzes, programming tasks, and essay submissions) available in the specific week.

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Bombay .It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team


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