Week 1: Overview of Drug Delivery Systems and Controlled Drug Delivery Systems
1.1. Introduction, terminology/definitions and rationale, advantages, disadvantages, and selection of drug candidates.
1.2. Approaches to design-controlled release formulations based on diffusion, dissolution and ion exchange principles.
1.3. Physicochemical and biological properties of drugs relevant to controlled release formulations
Week 2: Materials used in drug delivery system
Introduction, classification, properties, advantages, and application of the following materials in drug delivery systems
2.1. Polymer
2.2. Lipids
2.3. Inorganic materials
2.4. Hybrid materials
Week 3: Types of Nanocarrier Systems
Introduction, preparation, and evaluation of the following nanocarriers
3.1. Polymer-based nanocarriers
3.2. Lipid-based nanocarriers
3.3. Inorganic-based nanocarriers
3.4. Vesicular systems: Niosomes, Ethosomes, and Transfersomes
Week 4: Targeted Drug Delivery systems
4.1. Basics or Fundamentals of Targeted Drug Delivery
4.2. Need for targeted drug delivery, ligand-receptor interaction, levels of targeting
4.3. Active and passive targeting, EPR effects, receptor-mediated endocytosis, and a Multifunctional approach in targeted drug delivery, Stimuli responsive (Magnetic, thermal and pH) systems
4.4. Special focus on Tumor and Brain delivery
Week 5: Mucosal Drug Delivery System
5.1. Introduction, Principles of bioadhesion / mucoadhesion, concepts, advantages and disadvantages,
5.2. Transmucosal permeability and
5.3. Formulation considerations of buccal delivery systems
Week 6: Ocular Drug Delivery Systems
6.1 Introduction, intra ocular barriers and methods to overcome
6.2. Preliminary study, ocular formulations, ocuserts and NDDS
Week 7: Intranasal and Pulmonary drug delivery system
7.1. Introduction to Nasal routes of drug delivery, Formulation aspects:
7.2. In-Situ Gel Nasal Delivery, Nose-to-Brain Delivery
7.3. Introduction to Pulmonary routes of drug delivery, Formulation of
7.4. Inhalers (dry powder and metered dose), nasal sprays, nebulizers
Week 8: Transdermal Drug Delivery Systems
8.1. Introduction, Permeation through skin, factors affecting permeation,
8.2. Permeation enhancers, basic components of TDDS,
8.3. Formulation approaches
8.4. Importance of microneedles in transdermal drug delivery
Week 9: Oral Gastroretentive drug delivery systems (GRDDS) and Microencapsulation
9.1. Introduction, advantages, disadvantages,
9.2. Approaches for GRDDS, Floating, high-density systems, inflatable and gastroadhesive systems and their applications
9.3. Definition, advantages and disadvantages, microspheres or microcapsules, microparticles,
9.4. Methods of microencapsulation, applications
Week 10: Intrauterine Drug Delivery Systems
10.1. Introduction, advantages and disadvantages, development of intra uterine devices (IUDs) and applications
Implantable Drug Delivery Systems
10.2. Introduction, advantages and disadvantages, concept of implants and osmotic pump
Week 11: Protein/ Peptide and Nucleic acid Delivery Systems
11.1. Introduction, Barriers for protein delivery and Nucleic acid delivery,
11.2. Formulation and Evaluation of delivery systems
Week 12: Scalability and Regulatory Perspective of Novel drug delivery systems
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