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Novel Drug Delivery Systems

By Prof. Sathish Dyawanapelly   |   Institute of Chemical Technology, Mumbai
Learners enrolled: 510
ABOUT THE COURSE:

This course provides the knowledge about the various strategies for development and evaluation of Novel Drug Delivery Systems (NDDS) and targeted delivery which includes controlled drug delivery systems, nanocarriers (polymeric, lipid, metal), mucosal delivery, implantable delivery, transdermal delivery, gastro-retentive delivery, intranasal, pulmonary, ocular, intrauterine delivery system for delivery of drugs and biological molecules such as DNA, siRNA, proteins and peptides. It also covers Scalability and Regulatory Perspective of Novel drug delivery systems. The NDDS course is designed based on B. Pharmacy and M. Pharmacy syllabi approved by Pharmacy Council of India (PCI) which is adopted uniformly by all the pharmacy institutions and Universities throughout India. All other learners who want to learn the basics of NDDS, targeted drug delivery, nanopharmaceuticals can get the vital benefit out of this course.

INTENDED AUDIENCE: UG, PG, PhD students and research scientists in pharmaceutical sciences, biotechnology, material science and metallurgy, surgeons, clinicians, dentists

PREREQUISITES: A course in pharmacy, nanoscience, basics of Bioscience and Bioengineering

INDUSTRY SUPPORT: All Pharmaceutical, Biotechnology, Implants, devices, Biomaterials Industries ZIM LABORATORIES LIMITED https://www.zimlab.in/blog-posts/emerging-trends-in-novel-drug-delivery-systems-whats-on-the-horizon
Summary
Course Status : Upcoming
Course Type : Elective
Language for course content : English
Duration : 12 weeks
Category :
  • Chemical Engineering
  • Polymers and Colloidal Materials
Credit Points : 3
Level : Undergraduate/Postgraduate
Start Date : 21 Jul 2025
End Date : 10 Oct 2025
Enrollment Ends : 28 Jul 2025
Exam Registration Ends : 15 Aug 2025
Exam Date : 01 Nov 2025 IST
NCrF Level   : 4.5 — 8.0

Note: This exam date is subject to change based on seat availability. You can check final exam date on your hall ticket.


Page Visits



Course layout

Week 1:  Overview of Drug Delivery Systems and Controlled Drug Delivery Systems
 1.1. Introduction, terminology/definitions and rationale, advantages, disadvantages, and selection of drug candidates.
 1.2. Approaches to design-controlled release formulations based on diffusion, dissolution and ion exchange principles.
 1.3. Physicochemical and biological properties of drugs relevant to controlled release formulations

Week 2: Materials used in drug delivery system
 Introduction, classification, properties, advantages, and application of the following materials in drug delivery systems
 2.1. Polymer
 2.2. Lipids
 2.3. Inorganic materials
 2.4. Hybrid materials

Week 3: Types of Nanocarrier Systems
 Introduction, preparation, and evaluation of the following nanocarriers
 3.1. Polymer-based nanocarriers
 3.2. Lipid-based nanocarriers
 3.3. Inorganic-based nanocarriers
 3.4. Vesicular systems: Niosomes, Ethosomes, and Transfersomes

Week 4: Targeted Drug Delivery systems
 4.1. Basics or Fundamentals of Targeted Drug Delivery
 4.2. Need for targeted drug delivery, ligand-receptor interaction, levels of targeting
 4.3. Active and passive targeting, EPR effects, receptor-mediated endocytosis, and a Multifunctional approach in targeted drug delivery, Stimuli         responsive (Magnetic, thermal and pH) systems
 4.4. Special focus on Tumor and Brain delivery

Week 5: Mucosal Drug Delivery System
 5.1. Introduction, Principles of bioadhesion / mucoadhesion, concepts, advantages and disadvantages,
 5.2. Transmucosal permeability and
 5.3. Formulation considerations of buccal delivery systems

Week 6: Ocular Drug Delivery Systems
 6.1 Introduction, intra ocular barriers and methods to overcome
 6.2. Preliminary study, ocular formulations, ocuserts and NDDS

Week 7: Intranasal and Pulmonary drug delivery system
 7.1. Introduction to Nasal routes of drug delivery, Formulation aspects:
 7.2. In-Situ Gel Nasal Delivery, Nose-to-Brain Delivery
 7.3. Introduction to Pulmonary routes of drug delivery, Formulation of
 7.4. Inhalers (dry powder and metered dose), nasal sprays, nebulizers

Week 8: Transdermal Drug Delivery Systems
 8.1. Introduction, Permeation through skin, factors affecting permeation,
 8.2. Permeation enhancers, basic components of TDDS,
 8.3. Formulation approaches
 8.4. Importance of microneedles in transdermal drug delivery

Week 9: Oral Gastroretentive drug delivery systems (GRDDS) and Microencapsulation
 9.1. Introduction, advantages, disadvantages,
 9.2. Approaches for GRDDS, Floating, high-density systems, inflatable and gastroadhesive systems and their applications 
 9.3. Definition, advantages and disadvantages, microspheres or microcapsules, microparticles,
 9.4. Methods of microencapsulation, applications

Week 10: Intrauterine Drug Delivery Systems
 10.1. Introduction, advantages and disadvantages, development of intra uterine devices (IUDs) and applications
 Implantable Drug Delivery Systems
 10.2. Introduction, advantages and disadvantages, concept of implants and osmotic pump

Week 11: Protein/ Peptide and Nucleic acid Delivery Systems
 11.1. Introduction, Barriers for protein delivery and Nucleic acid delivery,
 11.2. Formulation and Evaluation of delivery systems

Week 12: Scalability and Regulatory Perspective of Novel drug delivery systems

Books and references

  1.  Y W. Chien, Novel Drug Delivery Systems, 2nd edition, revised and expanded, Marcel Dekker, Inc., New York, 1992.
  2.  Robinson, J. R., Lee V. H. L, Controlled Drug Delivery Systems, Marcel Dekker,Inc., New York, 1992.
  3.  Encyclopedia of controlled delivery, Editor- Edith Mathiowitz, Published by WileyInterscience Publication, John Wiley and Sons, Inc, New York/Chichester/Weinheim
  4.  N.K. Jain, Controlled and Novel Drug Delivery, CBS Publishers & Distributors, New Delhi, First edition 1997 (reprint in 2001).
  5.  S.P.Vyas and R.K.Khar, Controlled Drug Delivery - concepts and advances,Vallabh Prakashan, New Delhi, First edition 2002.
  6.  Devarajan, Padma V., and Sanyog Jain, eds. "Targeted drug delivery: concepts and design." (2015).

Instructor bio

Prof. Sathish Dyawanapelly

Institute of Chemical Technology, Mumbai
Dr. Sathish Dyawanapelly is an Assistant professor (Pharmaceutics) at the Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology (ICT/UDCT), Mumbai, India. He holds a distinguished PhD (Tech) degree in Pharmaceutics (ICT-Mumbai) and master’s degree in Pharmaceutics (NIPER-Raebareli). He has more than 7 years of experience in teaching and research. His scientific interests are in Design and Development of Novel Drug Delivery Systems (Polymer, Lipid, and Metal Nanoparticles), Disease targeted Nanomedicines, and Nutraceuticals. He has actively engaged in industry projects that translate science into technologies that can be used in the clinic. He has published over 30 research and review articles in peer-reviewed international journals and authored in numerous book chapters. He is an Editor for the book entitled “Advances in Stimuli-responsive Nanosystems for Cancer Therapy”, Springer Nature Group [Under review, Expected Publication Year: 2025]. He is also an Editorial member for the Scientific Reports (Nature), PLOS ONE, Frontiers in Drug Delivery, Discover Pharmaceutical Sciences (Springer), and Current Indian Science (Bentham Science). He serves as a reviewer for more than 30 international journals. More information at https://www.ictmumbai.edu.in/emp_profiledetail.aspx?nDeptID=cmakcs

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: November 01, 2025 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

Please note that assignments encompass all types (including quizzes, programming tasks, and essay submissions) available in the specific week.

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Bombay .It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team


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