Week 1: Laboratory animals: Ethics of animal research
1. Morals of Animal Testing and 3R Principles
2. Common Laboratory Animals and Their Maintenance: Part A
3. Common Laboratory Animals and Their Maintenance: Part B
4. CCSEA Guidelines to Experiment on Animals- Part A
5. CCSEA Guidelines to Experiment on Animals Part B
Week 2: Alternatives to animal experimentation
1. Form B: Application for IAEC Approval
2. Anaesthesia and Euthanasia of Experimental Animals
3. Alternatives to Animal Usage in Research
4. In-vitro Models
5. Stem Cell Therapy, Skin Patch Test
Week 3: Drug Screening Approaches
1. In-silico Models, Microfluidic chips, Recent trends
2. High-throughput Screening (HTS) Assays
3. Western Blotting
4. Assay and its Types
5. Classification of Bioassays
Week 4: Models for Alzheimer’s disease and Parkinson’s disease
1. Introduction to Alzheimer’s disease
2. Symptoms and Pathophysiology of Alzheimer’s Disease
3. Screening Models of Alzheimer’s disease
4. Introduction to Parkinson’s Disease
5. Models of Parkinson’s disease
Week 5: Anti-Depressant Screening Models
1. Introduction to Depression
2. Diagnosis & Pharmacotherapeutics for the Treatment of Depression
3. Models for the Screening of Anti-depressent Drugs
4. Behavioral tests for the assessment of Anti-depressant activity
Week 6: Screening Models for Pain
1. Introduction to Pain and its Pathobiology
2. Preclinical model for neuropathic Pain
3. Preclinical models for inflammatory Pain
4. Behavior assays for pain measurement in animals
5. Behavior assays for Spontaneous Pain Assessment
Week 7: Screening Models for Anti-diabetic Activity
1. Introduction to Diabetes
2. Pathophysiology and diagnosis of Diabetes
3. Current Pharmacotherapeutics used for the Treatment of Diabetes Mellitus
4. In-Vitro Models of Diabetes Mellitus
5. In-ViVo Models of Diabetes Mellitus
Week 8: Advanced Pharmacological Screening Assays
1. Pharmacological Screening and its types
2. Transgenic animals: Production and maintenance
3. Humanized Mouse: Introduction
4. Applications of Transgenic Animals
5. Applications of Humanized mouse
Week 9: Introduction to Toxicology and Regulatory Guidelines
1. Introduction to Toxicology
2. Mechanism of Toxicity and Toxicant Action
3. Toxicity Testing Studies as per OECD Guidelines
4. ICH Guidelines for Drug Toxicity Studies
5. Good Laboratory Practices for Safety Studies
Week 10: Toxicological Investigation Methods
1. Acute and Sub-Acute Toxicity Studies
2. Chronic Toxicity Studies
3. Mutagenicity and Genotoxicity Studies
4. Teratogenicity Studies
5. Reproductive Toxicity
Week 11: Organ System Toxicology
1. Neurobehavioral Toxicology
2. Cardiovascular Toxicology
3. Respiratory Toxicology
4. Dermal/Skin Toxicology
5. Liver Toxicology
Week 12: Carcinogenicity Studies
1. Introduction to Carcinogenesis
2. Categories of Carcinogenicity Studies
3. Autophagy and Apoptosis
4. Apoptotic pathways and Necroptosis
5. Methods to Screen Anti-cancer Agents
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