Week 1:
1. Basics of regeneration: basics and types
2. Regeneration, Wound healing and Scar formation in different regenerative capacity
3. Regeneration: in normal life and implications
4. Tissue regeneration: mammalian context
5. Liver regeneration: Signaling events
Week 2:
6. Liver regeneration: mechanistic insights
7. Regeneration: lessons from animal model Hydra
8. Mechanisms of regeneration in Hydra
9. Asexual Reproduction- Fragmentation. Morphallaxis, Epimorphosis, lessons from Hydra
10. Mechanisms of regeneration in Planaria
Week 3:
11. Planaria regeneration-polarity and gradient in regeneration
12. Planaria regeneration: Neoblasts and organ formation
13. Planaria regeneration: Species type and enviornment
14. Position control genes and regeneration
15. Progenitor targeting and ectopic organs
Week 4:
16. Tissue dedifferentiation, cellular reprograming into blastema Cellular types in regeneration. Neural crest cells in vertebrates
17. Totipotency, pluripotency, multipotency and unipotency, in regeneration context
18. Adult stem cells: Natural and induced and their roles in regeneration-zebrafish
19. Common cellular events during regeneration, embryonic development, and cancer
20. Epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET) in regeneration
Week 5:
21. Organ regeneration: Basics with examples
22. Zebrafish fin regeneration-in a brief
23. Zebrafish heart regeneration-in a brief
24. Zebrafish retina regeneration-in a brief
25. Spinal cord and brain regeneration-Conclusive mechanisms of regeneration
Week 6:
26. Cellular, Molecular and Genetic factors involved in retina regeneration
27. Detailed mechanisms of fin regeneration
28. Retina regeneration-importance of Shh signaling Roles of epigenetic factors and their involvement in regeneration
29. Importance of regeneration associated gene induction events-Transcription activators and repressors
30. Roles of different cellular signaling in regeneration: Examples- Wnt signaling
Week 7:
31. Different cellular signaling during regeneration-Overview
32. Different cellular signaling during regeneration. Examples- Jak-STAT and Fgf signaling
33. Different cellular signaling during regeneration -Egf, and Hippo signaling
34. Roles of Delta-Notch signaling during regeneration
35. Tgf-beta signaling during regeneration
Week 8:
36. Organ regeneration: An overview
37. Accessory limb model of regeneration: lessons from Axolotl and newt
38. Nerve-dependent regeneration-Axolotl and Newt
39. Roles of Histone deacetylases in regeneration of vertebrates like fishes and amphibians
40. Dynamics of immune system in organ regeneration regeneration
Week 9:
41. Extracellular matrix and its roles in tissue regeneration
42. Induced pluripotency and roles if iPFs during tissue Hox genes and homeotic transformation
43. Animal cloning: implications in regeneration
44. Embryonic stem cells, cord blood stem cells and adult stem cells
45. Ethics of stem cell research in regeneration studies, regenerative medicine and biotechnology
Week 10:
46. Tissue engineering and-Why and how?
47. History of tissue engineering
48. Different steps in tissue engineering
49. Different aspects of organ culture
50. Major challenges in tissue engineering in practice
Week 11:
51. Tissue 3D printing and organ culture
52. Importance of scaffolds in tissue engineering
53. Stem cells for tissue engineering-Use of CRISPR-Cas9 for genome targeting
54. Types of adult stem cells and trans-differentiation for tissue engineering
55. Influence of niches and scaffolds on stem cells: An organ culture perspective
56. The basics of regeneration put into practice in vitro.
Week 12:
57. Adhesion, migration and aggregation of stem cells
58. Artificial, liver, kidney and urinary bladder for transplantation in patients
59. Limbal stem cells and artificial cornea
60. Xenotransplantation vs organ culture in practice
61. Future implications of regeneration in mammals
62. Future implications of Organ culture in patient care
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