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Microsensors, Implantable Devices and Rodent Surgeries for Biomedical Applications

By Prof. Hardik Jeetendra Pandya, Prof. Shabari Girishan K V   |   IISc Bangalore, Ramaiah University of Applied Sciences (RUAS)
Learners enrolled: 898   |  Exam registration: 24
ABOUT THE COURSE : Several branches of engineering involve the study of the nervous system. Engineering students of various branches are expected to understand the nervous system and perform neural surgical experiments on animal models. Rodent being the most common animal model used in the field of bioscience modules, it is important to know how to perform the surgical experiments themselves. The module is designed for students to understand the functioning of the nervous system without a detailed understanding of biology. Further, the students will be exposed to engineering opportunities in developing technologies for understanding the functioning of the nervous system.

INTENDED AUDIENCE : Engineering Students, Faculty from Engineering Colleges, Medical Students, Faculty from Medical Colleges.

PREREQUISITES : Preferable, but not essential, to have taken the NPTEL Sensors and Actuators.

INDUSTRY SUPPORT : MathWorks, Open BCI, Medtronic DBS systems, Neuroprosthetic device industries.
Summary
Course Status : Upcoming
Course Type : Elective
Language for course content : English
Duration : 12 weeks
Category :
  • Biological Sciences & Bioengineering
  • Bioengineering
Credit Points : 3
Level : Undergraduate/Postgraduate
Start Date : 20 Jan 2025
End Date : 11 Apr 2025
Enrollment Ends : 27 Jan 2025
Exam Registration Ends : 14 Feb 2025
Exam Date : 26 Apr 2025 IST

Note: This exam date is subject to change based on seat availability. You can check final exam date on your hall ticket.


Page Visits



Course layout

Week 1 : Logistics in rodent experiments: Personal Protective Equipment, Procurement and quarantine of laboratory animals, Husbandry and Handling of rodents, Breeding and Care of Rats and Mice.

Week 2 : 
Rodents for Neural experiments: Species of rodents used in neural experiments, Rodent identification, and selection for experiments

Week 3: 
Rodent Neural Sensors and Data acquisition systems, Epileptic Seizure Detection and Classification

Week 4 : 
Microbial and Health monitoring for chronic neural experiments.

Week 5 : 
Neural system models in rodents – Epilepsy, Stroke, Motor movements, Parkinsonian models and application of rodent neural experiments, Microfabrication for neural engineering, PVD, CVD, Lithography, Etching

Week 6 : 
Behavioral setups for neural experiments, Different Brain-Computer Interfaces, Micro Electrode Array

Week 7 : 
Rodent Micro Neurosurgery I: Rodent anesthesia techniques, Introduction, Neuroanatomy – Applied and Comparative (rodent /monkey/ human) Equipments, Sterility and sterilization, Craniotomy, Microneurosurgical instruments and techniques, Sensor implantation and head mounting techniques, Closure techniques and challenges, Implant care for chronic recordings

Week 8 : 
Rodent Micro Neurosurgery II: Spinal anatomy, Spinal cord sensors and implantation surgeries, Peripheral neural anatomy, Peripheral neural surgeries, Peripheral neural sensors, and implantation, Different neural experiments as an example, Recovery process, Biological Basis of Contemporary Neural Networks and Neural Substrates for Contemporary Neural Networks

Week 9 : 
Rodent neuropathology: Euthanasia and Brain harvesting techniques. Neuropathological processing of the harvested brain, Electronic System Development for neural experiments

Week 10 : 
Challenges in neural signals and synchronization of behaviors, Brain Stimulation: Introduction and Applications, Experimental Protocol for Neural Experiments

Week 11 : 
Neural signal processing and post-processing, EEGLAB, ERPLAB, Event-Related Potentials: Introduction and Applications, ERP Extraction, Time-Frequency Analysis, Signal Interpretation

Week 12 : 
Decoding techniques and challenges, Recent Trends in Neural Engineering

Books and references

1. Pallas-Areny, R. and Webster, J.G., 2012. Sensors and signal conditioning. John Wiley & Sons.
2. An Introduction to the Event-Related Potential Technique
3. The Oxford Handbook of Event-Related Potential Components
4. The Art of Electronics, Horowitz & Hill, 3rd Edition.
5. Principles of Neural Science, Fifth Edition. Eric R. Kandel, Edited, James H. Schwartz, Edited, Thomas M. Jessell, Edited, Steven A. Siegelbaum, Edited, A. J. Hudspeth, Edited, Sarah Mack, Art Editor
6. Paxinos and Watson: The Rat Brain

Instructor bio

Prof. Hardik Jeetendra Pandya

IISc Bangalore
Prof. Hardik J. Pandya is an Associate Professor in the Department of Electronic Systems Engineering, Division of EECS, and Associate Faculty, Department of Design and Manufacturing, Division of Mechanical Sciences, Indian Institute of Science, Bangalore. Dr. Pandya heads three laboratories in ESE focused on developing a new class of biomedical devices and technologies. Before joining IISc, he worked as a postdoctoral scientist in the Department of Mechanical Engineering, Maryland Robotics Center, University of Maryland, College Park (2012- 2016) and in the Department of Medicine, Brigham and Women's Hospital–Harvard Medical School (2016-2017). He obtained his Ph.D. in microengineering systems from the Indian Institute of Technology Delhi (2013). His lab comprises twenty- eight scholars (twelve Ph.D., ten M.Tech., and six project assistants). In the last six years and nine months, he graduated five Ph.D. scholars and fifteen M.Tech. scholars, in addition to guiding three postdoctoral fellows and several research staff. Alums from his lab have pursued roles in academia and prominent industries, joining esteemed institutions and companies like A*STAR, IMEC, IIITDM Kancheepuram, Intel, NVIDIA, MAXLINEAR, Texas Instruments, Samsung, IIT Gandhinagar, and Delft University. His current research focuses on minimally invasive and non-invasive technologies with an emphasis on but not limited to cancer diagnosis (brain, breast, head, and neck), e- nose (diabetes, breast cancer screening), and Neuroprotective Therapies for Acute Stroke and Epilepsy. He received the prestigious Early Career Research Award from the Science and Engineering Research Board, Government of India 2017. Dr. Pandya received the prestigious ISSS Award 2020 under the Young Scientist Award category for the work done in India in micro and smart systems. He also received Indian National Academy of Engineering (INAE) and Science and Engineering Research Board (SERB), Department of Science and Technology (DST) Abdul Kalam Technology Innovation National Fellowship in 2023. His work has resulted in five granted patents, eleven Indian patent applications, five international patent applications, three book chapters, and around sixty-five publications in peer-reviewed journals and conferences, including journals like Nature Microsystems and Nanoengineering, IEEE TBioCAS, IEEE Sensors, Journal of Biophotonics, and IEEE TBME. His work has been highlighted as "Breaking Research News" by The Physicians Committee for Responsible Medicine. The work on a portable cancer diagnosis tool was also featured in Science Translational Medicine as an Editorial Choice, Breast Cancer Diagnosis, March 2016, and has been highlighted on the CapeRay blog as "Biochips and Diagnostic tools" in April 2016. Dr. Pandya is a non- executive Director (Technical advisor) to two Indian MedTech companies. He is also the founder and Director of Scilogic Applied Research Private Limited, a Startup focused on translating biomedical devices and technologies to market.


Prof. Shabari Girishan K V

Ramaiah University of Applied Sciences (RUAS)
Prof. Shabari Girishan is an Associate Professor of Neurosurgery at RUAS, Bangalore. Besides clinical work, he has a deep interest in Deep tech development. He pursues independent programs on neurosurgical electrode fabrication, Fine motor movement neurosurgery, and novel imaging techniques and is pursuing a Ph.D. in Bio-systems Engineering at IISc-Bangalore. Additionally, he is a consultant epilepsy & functional neurosurgeon in Bangalore with over 10 years of experience in Neurosurgery. After MBBS and specializing in General Surgery from Bangalore Medical College, he secured the M.Ch. Degree in Neurosurgery from the prestigious institute of Christian Medical College, Vellore, the first Neurosurgical center to start in India. He continued to work as an assistant professor for 3 years in CMC, Vellore. He then completed 2 years of fellowship in the subspecialty of Epilepsy & Functional Neurosurgery at All India Institute of Medical Sciences, Delhi, ranked as the top medical institute in the country and an institute of national importance under the Central Government Ministry of Science and Technology. He is among the few neurosurgeons in India who can provide a surgical cure for epilepsy and do deep brain stimulation for Parkinson’s disease and other movement disorders. He holds academic posts and has many indexed publications and book chapters to his credit.

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: April 26, 2025 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

Please note that assignments encompass all types (including quizzes, programming tasks, and essay submissions) available in the specific week.

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IISc Bangalore .It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team


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