Cell Biology: Cellular organization, division and processes

By Prof. Shikha Laloraya | IISc Bangalore

Learners enrolled: 2905 | Exam registration: 293

ABOUT THE COURSE : This course focuses on cell organization, and the molecules and intracellular processes crucial for life and inheritance. A particular emphasis is on DNA transactions such as chromosome organization, replication, chromosome segregation, etc. Some examples of key discoveries in the field of cell cycle regulation, chromatin organization, and the dynamic processes and molecular machines involved in cell division will be discussed in detail. Other topics include Nuclear organization, Mitosis and Meiosis and cell death. In addition, cellular diversity will be discussed including selected specialized eukaryotic cells and their functions, cancer cells-how controls go wrong, and stem cells.
This course includes 8 modules and 33 lectures. It is intended for graduate students mainly M.Sc. students (or 1st year Ph.D. students). Final year B.Sc. students may also find it useful.

INTENDED AUDIENCE : Biology, Chemistry.

PREREQUISITES : Basic Molecular Biology, Genetics and Biochemistry. Especially basic structure and function of biomolecules including enzymes.

Summary

Course Status :	Upcoming
Course Type :	Core
Language for course content :	English
Duration :	8 weeks
Category :	Biological Sciences & Bioengineering Biosciences
Credit Points :	2
Level :	Undergraduate/Postgraduate
Start Date :	20 Jan 2025
End Date :	14 Mar 2025
Enrollment Ends :	27 Jan 2025
Exam Registration Ends :	14 Feb 2025
Exam Date :	22 Mar 2025 IST

Note: This exam date is subject to change based on seat availability. You can check final exam date on your hall ticket.

Page Visits

Course layout

Week 1:
Lecture 1-Introduction to Cell Biology, Cell components, organization and processes - Part I
Lecture 2- Introduction to Cell Biology, Cell components, organization and processes -Part II
Lecture 3- DNA: The genetic material. Part I
Lecture 4- DNA: The genetic material. Part II

Week 2:
Lecture 5- Regulation of the cell cycle-Part I
Lecture 6- Regulation of the cell cycle-Part II
Lecture 7-Checkpoints: The DNA damage and DNA replication checkpoints.
Lecture 8- The Ubiquitin Proteasome system

Week 3:
Lecture 9- S-phase: Regulation of entry into S-phase and DNA Replication.
Lecture 10- DNA replication-Part I
Lecture 11- DNA Replication-Part II.
Lecture 12-DNA Replication-Part III.

Week 4:
Lecture 13- Mitosis-Part I
Lecture 14- Mitosis-Part II
Lecture 15- Cytokinesis
Lecture 16- Centrosomes In Development, Evolution And Disease

Week 5:
Lecture 17- Meiosis Part I
Lecture 18- Meiosis Part II
Lecture 19- Meiosis Part III
Lecture 20-Nuclear Organization

Week 6:
Lecture 21- Chromatin organization
Lecture 22- SMC proteins and chromosome organization Introduction
Lecture 23- SMC proteins & chromosome organization Real-Time imaging of DNA loop-extrusion by SMC complex.
Lecture 24- The cohesin complex and its functions-The mysterious biological function of chromosome loops

Week 7:
Lecture 25-Cell death, Aging and Senescence
Lecture 26- Apoptosis Part I
Lecture 27- Apoptosis Part II
Lecture 28-The Cancer Cell

Week 8:
Lecture 29-Cell diversity and properties of specialized cells-Budding yeast as a model system.
Lecture 30-The Plant Cell
Lecture 31-Stem cells Part I. Introduction.
Lecture 32-Stem cells Part II. Using gene-edited stem cells and live imaging to study cell biology.
Lecture 33-Nerve cells

Books and references

Molecular Biology of the Cell. Alberts, et al.
Molecular Cell Biology. Lodish, et al.
The Cell: A Molecular Approach. Cooper and Hausman.

Instructor bio

Prof. Shikha Laloraya

IISc Bangalore

Work experience:I am a Professor of Biochemistry, I.I.Sc. I also was Associate Professor and Assistant Professor of Biochemistry, and a Wellcome Trust International Senior Research Fellow in Biomedical Science in India, at I.I.Sc. Academic background:I did my Ph.D. in Oncology, from the University of Wisconsin-Madison, U.S.A. and post-doctoral research at the Carnegie Institution of Washington, Dept. of Embryology, and the Howard Hughes Medical Institutes, in Baltimore, U.S.A. I obtained an M.Sc. degree from the Centre for Biotechnology, Jawaharlal Nehru University, and also studied Life Sciences at the School of Life Sciences, Devi Ahilya Vishwavidyalaya. I did my B.Sc. from Devi Ahilya Vishwavidyalaya, Indore. Selected Awards: -The Wellcome Trust International Senior Research Fellowship in Biomedical Science in India, The Wellcome Trust, UK. 2001-2006 -Howard Hughes Medical Institute Research Associate at the Carnegie Institution, Baltimore, MD, USA. 1997-1999 -The Wisconsin Power and Light Foundation Fellowship in Cancer Research, Mc Ardle Laboratory for Cancer Research, UW-Madison, USA. -The Ravindra Nath Tagore Janm Shatabdi Gold Medal for First Rank among Bachelors degree candidates in all disciplines in the university, Devi Ahilya University, Indore, India -The Prerna Club Gold Medal for First Rank among women in B.Sc., Devi Ahilya University, Indore, India -Chintamani award for First Rank in the University for B.Sc., Devi Ahilya University, Indore, India. My general expertise is Molecular Genetics, Cell Biology and Biochemistry and my current research interests are Chromosome organization, Gene expression, post-translational modfications of proteins, Mitosis, and Cell Cycle. More information at: https://www.researchgate.net/profile/Shikha_Laloraya https://biochem.iisc.ac.in/shikha-laloraya.php

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.

The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).

Date and Time of Exams: March 22, 2025 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.

Registration url: Announcements will be made when the registration form is open for registrations.

The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.

Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 6 assignments out of the total 8 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

Please note that assignments encompass all types (including quizzes, programming tasks, and essay submissions) available in the specific week.

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IISc Bangalore .It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team