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Biomedical Ultrasound: Fundamentals of Imaging and Micromachined Transducers

By Prof. Karla P. Mercado-Shekhar, Prof. Himanshu Shekhar, Prof. Hardik Jeetendra Pandya   |   IIT Gandhinagar, IISc Bangalore
Learners enrolled: 1745   |  Exam registration: 264
ABOUT THE COURSE:
Ultrasound is growing rapidly as a diagnostic modality due to its low cost, non-ionizing nature, and portability, and has the potential to significantly impact healthcare delivery. This course will provide the conceptual foundations and practical insights for the use of ultrasound imaging, encompassing physics, instrumentation, signal generation, image reconstruction, and clinical applications. There is great interest in cutting edge research on biomedical ultrasound electronic system development and validation. Microfabricated transducers represent a new frontier in ultrasound, promising better performance and reduced complexity and cost. However, to employ microfabrication multidisciplinary expertise is necessary. This course offers exposure to the right mix of concepts in biomedical ultrasound along with microfabrication for techniques to develop transducers.

INTENDED AUDIENCE: Engineering Students, Research Students, Faculty from Engineering Colleges, Medical Students, Faculty from Medical Colleges

PREREQUISITES: UG third year students in ECE, Instrumentation, Physics, MMBS, can take this course.

INDUSTRY SUPPORT: MathWorks, Phillips, Siemens, GE, Samsung, Fujifilm, Canon, Verasonics
Summary
Course Status : Completed
Course Type : Elective
Language for course content : English
Duration : 12 weeks
Category :
  • Multidisciplinary
  • Electrical, Electronics and Communications Engineering
  • Biological Sciences & Bioengineering
  • Control and Instrumentation
  • Bioengineering
Credit Points : 3
Level : Undergraduate/Postgraduate
Start Date : 22 Jul 2024
End Date : 11 Oct 2024
Enrollment Ends : 05 Aug 2024
Exam Registration Ends : 16 Aug 2024
Exam Date : 26 Oct 2024 IST

Note: This exam date is subject to change based on seat availability. You can check final exam date on your hall ticket.


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Course layout

Week 1:  Basics of wave propagation, acoustic impedance

Week 2: Spatial intensity metrics, attenuation, reflection

Week 3: Scattering, refraction, focusing, speckle

Week 4: Piezoelectricity, electrical and mechanical modeling, matching and backing layers, effect on impedance, material properties, piezopolymers, composites, Micromachined Ultrasound Transducers

Week 5: Introduction: Clean Room Classification, Clean Room Protocols, and Clean Room Lab Demonstrations

Week 6: Microfabrication: PVD, CVD, Wet Etching

Week 7: Microfabrication: Lithography and Micromachining

Week 8: Transducer arrays, apodization, array beamforming, delay-and-sum, basics of Doppler processing

Week 9: Imaging modes, Image reconstruction

Week 10: Imaging artifacts, bioeffects of ultrasound, Safety, New Frontiers (eg. Elastography)

Week 11: Lab Experiment Demonstrations: Thermal Evaporation, E-Beam Evaporation, and Sputtering for Transducer Fabrication

Week 12: Photolithography Tool Demonstrations and a complete process flow demonstration for the fabrication of pMUTs

Books and references

• Pallas-Areny, R. and Webster, J.G., 2012. Sensors and signal conditioning. John Wiley & Sons.
• The Art of Electronics, Horowitz & Hill, 3rd Edition.
• Fundamentals of Microfabrication by Madou Marc J
• Duck FA, Baker AC, Starritt, HC, Ultrasound in Medicine, CRC Press, 2020.
• Szabo T, Diagnostic Ultrasound Imaging: Inside Out, 2nd Edition, Amsterdam: Academic Press,2014.

Instructor bio

Prof. Karla P. Mercado-Shekhar

IIT Gandhinagar
Prof. Karla Mercado-Shekhar is an Assistant Professor in the Department of Biological Sciences and Engineering and the Co-coordinator for the Centre of Biomedical Engineering at IIT Gandhinagar. She co-leads the Medical Ultrasound Engineering (MUSE) Lab, which focuses on developing and translating ultrasound techniques to aid in the diagnosis, treatment, and management of diseases. She received her Bachelor’s degree in Biomedical Engineering from Boston University, U.S.A. (2009) and her Masters (2010) and Ph.D. (2015) in Biomedical Engineering from the University of Rochester, U.S.A., as a Provost’s Fellow. She was a Postdoctoral Fellow at the University of Cincinnati College of Medicine (2014-2019) and a recipient of a postdoctoral research grant from the U.S.A. National Institutes of Health. Prof. Mercado-Shekhar joined IIT Gandhinagar in 2019. Her research group focuses on integrating the understanding of biological and physical mechanisms with technology to address healthcare challenges. Her group is actively exploring advanced ultrasound imaging techniques, such as shear wave elastography, ultrafast Doppler imaging, and quantitative backscatter imaging, to characterize diseased tissues synergistically based on their stiffness, vascular hemodynamics, and acoustic response. Prof. Mercado-Shekhar serves in the Technical Program Committee of the IEEE International Ultrasonics Symposium and the Biomedical Acoustics and Education in Acoustics Technical Committee of the Acoustical Society of America.


Prof. Himanshu Shekhar

Prof. Himanshu Shekhar is an Assistant Professor of Electrical Engineering at the Indian Institute of Technology Gandhinagar, India, where he co-leads the Medical Ultrasound Engineering (MUSE) Laboratory. He obtained a bachelor’s degree in Electronics and Communication Engineering from Manipal Institute of Technology, India (2008), and a Master’s (2010) and Ph.D. (2014) in Electrical Engineering from the University of Rochester, U.S.A. Prof. Shekhar trained as a postdoctoral fellow (2014 – 2019) at the University of Cincinnati College of Medicine, U.S.A. His research is focused on ultrasound mediated therapy, molecular imaging, and sensing. His research has been recognized with the F. V. Hunt Postdoctoral Fellowship, Howard Hughes Medical Institute’s Med-into-Grad Fellowship, best paper awards from the Acoustical Society of America, the Har Govind Korana Innovative Young Biotechnologist Award, and the Star Ambassador Lectureship Award from the IEEE UFFC Society. Prof. Shekhar currently serves on the Technical Committee on Biomedical Acoustics of the Acoustical Society of America and the IEEE International Ultrasonics Syposium Technical Committee (Group 2).


Prof. Hardik Jeetendra Pandya

IISc Bangalore
Prof. Hardik J. Pandya is an Associate Professor in the Department of Electronic Systems Engineering, Division of EECS, and Associate Faculty, Department of Design and Manufacturing, Division of Mechanical Sciences, Indian Institute of Science, Bangalore. Dr. Pandya heads three laboratories in ESE focused on developing a new class of biomedical devices and technologies. Before joining IISc, he worked as a postdoctoral scientist in the Department of Mechanical Engineering, Maryland Robotics Center, University of Maryland, College Park (2012- 2016) and in the Department of Medicine, Brigham and Women's Hospital–Harvard Medical School (2016-2017). He obtained his Ph.D. in microengineering systems from the Indian Institute of Technology Delhi (2013). His lab comprises twenty- eight scholars (twelve Ph.D., ten M.Tech., and six project assistants). In the last six years and nine months, he graduated five Ph.D. scholars and fifteen M.Tech. scholars, in addition to guiding three postdoctoral fellows and several research staff. Alums from his lab have pursued roles in academia and prominent industries, joining esteemed institutions and companies like A*STAR, IMEC, IIITDM Kancheepuram, Intel, NVIDIA, MAXLINEAR, Texas Instruments, Samsung, IIT Gandhinagar, and Delft University. His current research focuses on minimally invasive and non-invasive technologies with an emphasis on but not limited to cancer diagnosis (brain, breast, head, and neck), e- nose (diabetes, breast cancer screening), and Neuroprotective Therapies for Acute Stroke and Epilepsy. He received the prestigious Early Career Research Award from the Science and Engineering Research Board, Government of India 2017. Dr. Pandya received the prestigious ISSS Award 2020 under the Young Scientist Award category for the work done in India in micro and smart systems. He also received Indian National Academy of Engineering (INAE) and Science and Engineering Research Board (SERB), Department of Science and Technology (DST) Abdul Kalam Technology Innovation National Fellowship in 2023. His work has resulted in five granted patents, eleven Indian patent applications, five international patent applications, three book chapters, and around sixty-five publications in peer-reviewed journals and conferences, including journals like Nature Microsystems and Nanoengineering, IEEE TBioCAS, IEEE Sensors, Journal of Biophotonics, and IEEE TBME. His work has been highlighted as "Breaking Research News" by The Physicians Committee for Responsible Medicine. The work on a portable cancer diagnosis tool was also featured in Science Translational Medicine as an Editorial Choice, Breast Cancer Diagnosis, March 2016, and has been highlighted on the CapeRay blog as "Biochips and Diagnostic tools" in April 2016. Dr. Pandya is a non- executive Director (Technical advisor) to two Indian MedTech companies. He is also the founder and Director of Scilogic Applied Research Private Limited, a Startup focused on translating biomedical devices and technologies to market.

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 
26 October 2024 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Gandhinagar. It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team


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