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Introduction to Cell Biology

By Prof. Nagaraj Balasubramanian, Prof. Girish Ratnaparkhi   |   IISER Pune
Learners enrolled: 6689   |  Exam registration: 1967
ABOUT THE COURSE:
This course aims to introduce students to biomolecules and important fundamental concepts in cellular biochemistry, genetics and cellular organisation. It is aimed to give you an insight into how biomolecules work and help drive cellular architecture and function in a eukaryotic cell. In the first part, we focus on the information that makes the cell tick; from its storage in DNA to its conversion to executive molecules such as RNA and protein that perform essential routine processes in the cell. The central dogma is used as a guide to explore the structure of DNA, RNA and Protein and also explore the mechanisms of DNA replication, transcription and translation. Also touched upon are other important molecules such as water, carbohydrates and lipids. In the second part, we introduce basic mechanisms of heredity, as discovered by Gregor Mendel, in a modern context. In the third part, we will be discussing cell theory and the evolution of complexity in cells and the role compartmentalisation plays in mediating the same. The organisation of cells starting from the cell membrane as we move into the cell will be discussed. We will be looking at the role cytoskeleton have in cellular organisation and function. We will also be discussing organisation, role and regulation of cell organelles, everything from the endomembrane system to lysosomes to the nucleus. Eventually, we will be briefly discussing how all these cellular components come together to drive the process of cell division.

INTENDED AUDIENCE: First year undergraduate Biology students

PREREQUISITES: Any student who is starting a BSc course in Biology would find this useful.

INDUSTRY SUPPORT: Biotech companies may find this course useful for technicians and students who train with them.
Summary
Course Status : Ongoing
Course Type : Core
Duration : 8 weeks
Category :
  • Biological Sciences & Bioengineering
  • Biosciences
Credit Points : 2
Level : Undergraduate
Start Date : 19 Aug 2024
End Date : 11 Oct 2024
Enrollment Ends : 19 Aug 2024
Exam Registration Ends : 30 Aug 2024
Exam Date : 26 Oct 2024 IST

Note: This exam date is subject to change based on seat availability. You can check final exam date on your hall ticket.


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Course layout

Week 1: Overview of the Central Dogma of Molecular Biology. Storage and information flow within the cell. The Central Dogma: DNA replication
Week 2: The Central Dogma: Transcription & Translation
Week 3: Macromolecules in the cell: Proteins, Carbohydrates and Lipids. The rules governing heredity: A short introduction to Genetics
Week 4: Introduction to microscopy. Prokaryotes vs Eukaryotes, evolution of complexity and the endosymbiont theory
Week 5: Cell Membrane. Why lipids? Membrane organisation and function. Cytoskeleton components, how are they similar and different? How does this help their distinct function.
Week 6: Motor proteins, their evolution, specificity, directionality, and function in cells.
Week 7: The endomembrane system & Nucleus. ER, Golgi, lysosomes and vacuoles. Their assembly, crosstalk and function in cells.
Week 8: How does the endomembrane system connect to the nucleus. The organisation of the nucleus. The role of cell membrane, organelles and cytoskeleton in cell division. How does the cell manage to use these component to distribute its content evenly between daughter cells?

Books and references

  1. Voet, D., Voet, J.G (2010). Biochemistry, 4th edition, Wiley.
  2. Harper’s Ilustrated Biochemistry (2009), 28th edition, McGraw Hill.
  3. Campbell and Reece (2005) Biology, 7th edition, Pearson Publishing.
  4. Raven, Johnson, Losos and Singer (2005) Biology, 7th edition, McGraw Hill.
  5. Alberts, Bray, Hopkin, Johnson, Lewis, Raff, Roberts and Walters (2003), Essential cell biology, 2nd edition, Garland.
  6. Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith; Roberts, Peter Walter. (2007). 7) Molecular Biology of the Cell. 5th Edition. Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2005)

Instructor bio

Prof. Nagaraj Balasubramanian

IISER Pune
Prof. Nagaraj Balasubramanian graduated from the University of Mumbai (Bombay) with a bachelors and masters degrees in Microbiology. He worked in the Cancer Research Institute (now ACTREC) at the Tata Memorial Center for his PhD in Biochemistry. He took a break from cancer biology to do a postdoc in mammalian phototransduction at the University of Miami, only to return to cell and cancer biology focusing on cell adhesion and trafficking at the University of Virginia. He moved to IISER Pune to start his lab in 2010. His lab is interested in understanding how cell adhesion regulates trafficking and its implications in cell migration and anchorage dependence in 2D and 3D microenvironments. They are further exploring the role cell adhesion has in regulating organelle function and its implications in anchorage-dependent signalling and function.


Prof. Girish Ratnaparkhi

Prof. Girish Ratnaparkhi obtained his PhD from the Molecular Biophysics Unit, Indian Institute of Science, Bangalore. He had postdoctoral stints at the National Centre for Biological Sciences, Bangalore and the Department of Chemistry and Biochemistry at the University of California, Los Angeles in the USA before joining IISER Pune. His lab uses the fruifly Drosophila melanogaster to study animal development and disease. Broad research areas include cell signalling – especially in the immune response, maternal development, intra-organ signalling and neurodegeneration.

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 
26 October 2024 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 6 assignments out of the total 8 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IISER pune  .It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team


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