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Drug Delivery: Principles and Engineering

By Prof. Rachit Agarwal   |   IISc Bangalore
Learners enrolled: 5614   |  Exam registration: 1644
ABOUT THE COURSE:
This course introduces concepts of drug delivery to meet medical challenges. The course is designed to be modular, with each module focusing on the various aspects of drug delivery.


INTENDED AUDIENCE : Anyone in bachelors having completed two year

PREREQUISITES : A course in biochemistry, molecular biology, anatomy is recommended

INDUSTRY SUPPORT : All pharmaceuticals, hospitals and biotechnology industries
Summary
Course Status : Completed
Course Type : Elective
Language for course content : English
Duration : 12 weeks
Category :
  • Biological Sciences & Bioengineering
  • Bioengineering
Credit Points : 3
Level : Undergraduate/Postgraduate
Start Date : 22 Jul 2024
End Date : 11 Oct 2024
Enrollment Ends : 05 Aug 2024
Exam Registration Ends : 16 Aug 2024
Exam Date : 27 Oct 2024 IST

Note: This exam date is subject to change based on seat availability. You can check final exam date on your hall ticket.


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Course layout

Week 1 : Pharmacokinetics: Bioavailability, Elimination, Therapeutic index
Week 2 : Prodrugs, Controlled release
Week 3 : Polymers: Synthesis, properties, characterization, crystallinity and amorphousness 
Week 4 : Biopolymers: Natural and Synthetic, biocompatibility, Biodegradation, commonly used biopolymers
Week 5 : Polymer-Drug conjugates, PEGylation
Week 6 : Diffusion controlled systems, Ficks laws, Reservoir systems, Non-erodible matrix systems, Bio-erodible Systems
Week 7 : Hydrogels: Physical or chemical, pore-size calculation, in-situ crosslinking
Week 8 : Nano and Micro-particles: Dendrimers, Liposomes, Micelles 
Week 9 : Metal and polymeric particles, effect of particle shape, charge and elasticity
Week 10: Protein Adsorption and tissue engineering, Drug delivery in tissue engineering
Week 11: Implant associated infections, Route specific delivery: Oral, Subcutaneous, Intramuscular, transdermal, inhalation, intravenous
Week 12: Vaccines, Cancer vaccines, Cell and gene delivery, Smart responsive drug delivery, Targeted drug delivery, Nanotoxicology and market translation 

Books and references

  1. Drug Delivery: Engineering Principles for Drug Therapy, W. Mark Saltzman, Oxford University Press, 2001
  2. Drug Delivery: Fundamentals and Applications, Anya M. Hillery and Kinam Park, 2nd Edition, CRC Press, 2016

Instructor bio

Prof. Rachit Agarwal

IISc Bangalore
Rachit Agarwal is an associate professor at the Indian Institute of Science, Bangalore, India. He did his undergraduate studies at the Indian Institute of Technology, Kharagpur, India in Biotechnology. Rachit then worked in the field of biomaterial-based drug delivery for his PhD. at the University of Texas at Austin, Texas, USA. His post-doctoral fellowship was in regenerative medicine at the Georgia Institute of Technology, Atlanta, USA. His scientific interests are in developing biomaterial-based delivery vehicles for the treatment of inflammatory and infectious diseases. He is a recipient of the prestigious Ramanujan fellowship, Har-Gobind Khorana Young Biotechnologist award, and DBT/Wellcome Trust India Alliance Intermediate Fellowship. He is also the early career editorial board member for the Journal of Biomedical Materials Research Part A (JBMR-A). Two major areas of interest are in the treatment of Osteoarthritis and using inhalable biomaterials for the prevention and treatment of lung infections to translate science into technologies that can be used in the clinic. More information at https://be.iisc.ac.in/~rachit/

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 
27 October 2024 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IISc Bangalore .It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team


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