Advances in Omics

By Prof. Nagarjun Vijay | IISER Bhopal

Learners enrolled: 1245 | Exam registration: 122

ABOUT THE COURSE:
The course begins with a historical perspective to genomics and how the human genome project catalyzed the development of Next-Generation sequencing technologies. Instead of following a standard textbook format of chapters, the course is designed to use the latest articles in leading journals to keep the course focused on the recent advances in the field. However, the course is well grounded in the basics and exposes the students to practical NGS data analysis. In contrast to traditional course on genomics and proteomics, this course has a strong evolutionary flavor.

INTENDED AUDIENCE: BE/ME/MS/BSc/MSc/PhD

PREREQUISITES: Basics of biological molecules

Summary

Course Status :	Completed
Course Type :	Elective
Language for course content :	English
Duration :	8 weeks
Category :	Biological Sciences & Bioengineering Computational Biology
Credit Points :	2
Level :	Postgraduate
Start Date :	22 Jul 2024
End Date :	13 Sep 2024
Enrollment Ends :	05 Aug 2024
Exam Registration Ends :	16 Aug 2024
Exam Date :	21 Sep 2024 IST

Note: This exam date is subject to change based on seat availability. You can check final exam date on your hall ticket.

Page Visits

Course layout

Week 1: Introduction to genomics: Historical perspective with examples from Human genome project and Advent of NGS. Genomic assembly approaches.

Week 2: Detailed discussion of the principles of sequencing technologies and comparison of advantages and disadvantages. Applications and Challenges in the use of NGS technologies

Week 3: Omics data avalanche: 1000 genomes project, ENCODE project, ExAC, TCGA

Week 4: Importance of evolutionary viewpoint in genomics, Signatures of selection in primates (with prominent examples from Human studies), Whole-genome duplication, comparative and population genomics, tests of selection (codon based and site frequency-based tests).

Week 5: Introduction to transcriptomics, proteomics and Integration of Multi-Omic data. Other types of omic datasets resulting from high-throughput use of assays (Ex: Repli-Seq, Ribo-Seq, Tag-Seq)

Week 6: Omics databases organization and utility. NCBI, UCSC genome browser, Short Read Archive, Proteome Exchange, Peptide Atlas, KEGG

Week 7: Introduction to linux, use of command line interface, Tutorial on analysis of NGS data (Genomics, Transcriptomics)

Week 8: Course summary and Exam

Books and references

Selected Readings: Latest papers and review articles in each topic (from journals including, but not limited to, Nature, Curr. Opin. Chem. Biol., Cell, Nature Biotech., Science, Trends series). This will be provided in the class.

Instructor bio

Prof. Nagarjun Vijay

IISER Bhopal

Prof. Nagarjun Vijay is an Assistant Professor in the Department of Biological Sciences, IISER Bhopal. His work at the Computational Evolutionary Genomics (CEG lab), IISER Bhopal has focused on the study of gene loss using large-scale genomic datasets. The Department of Biotechnology, Government of India accorded him with the Har Gobind Khorana- Innovative Young Biotechnologist Award (HGK-IYBA) for his research on genomics of the chicken. The past few decades have seen an avalanche of biological data that has stimulated unexpected new discoveries. Omics technologies have been the major source

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 21 September 2024 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 6 assignments out of the total 8 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IISER Bhopal. It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team

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