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Host-Pathogen Interaction (Immunology)

By Prof. Himanshu Kumar   |   IISER Bhopal
Learners enrolled: 230
ABOUT THE COURSE:
This course introduces about fundamental aspects of Host (mainly human and mouse) defense system and also discusses how our immune system develops immunity against foreign living and non-living entities. This course will excellent for Bachelor, Master or Research level students from different disciplines of Biological Sciences, Biotechnology, Chemical Sciences and Medical Sciences to understand the basics of host defense system.

PREREQUISITES: Should have Bachelor’s degree in Biological Sciences with knowledge in Biochemistry, Molecular Biology, Animal Physiology

INDUSTRY SUPPORT: Biotechnology, Pharma, Vaccine, Medical diagnostic
Summary
Course Status : Upcoming
Course Type : Core
Duration : 12 weeks
Start Date : 23 Jan 2023
End Date : 14 Apr 2023
Exam Date : 29 Apr 2023 IST
Enrollment Ends : 30 Jan 2023
Category :
  • Biological Sciences & Bioengineering
Credit Points : 3
Level : Postgraduate

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Course layout

Week 1:  History of development of Immunology field; Branches of Immunology & An Introduction of Immune System; Overall Introduction of Immune Organ.
Week 2: Immune organ: Thymus & Bone Marrow; Immune organ: Spleen, lymph node, MALT & GALT; Cells of Immune system – Hematopoiesis & Usage of early stem cells in transgenesis.
Week 3: Cells of Immune system – Development of transgenic animal for immunological studies; Cells of Immune system – Application of transgenic animal for immunological studies; Cells of Immune system – Various immune cells and its role in host defense and immunopathogenesis.
Week 4: Basics of cytokines and other immune mediators; Signature of inflammation & various Inflammatory mediators and other effector immune responses; Application of cytokines in therapies and research.
Week 5: Introduction of innate immunity and how innate immunity influence whole immunity; Innate Immunity-Physical, Biochemical, Microbial Barriers; Innate Immunity-Pattern-recognition receptors & TLRs.
Week 6: Innate Immunity-RLRs; Innate Immunity-NLRs; Innate Immunity-DNA Sensor.
Week 7: Innate Immunity-Humoral components (Introduction of Complements & classical pathway); Innate Immunity- (Alternative & Lectin pathway) and complements and diseases; Adaptive Immunity (Introduction).
Week 8: Antigen – A brief Introduction; B cells & Antibodies – A brief Introduction; T cells & T Cell response – A brief Introduction.
Week 9: Brief introduction on innate immune responses during virus infection and how virus invade innate immunity to establish infection (part-1); Brief introduction on innate immune responses during virus infection and how virus invade innate immunity to establish infection (part-2); Brief discussion on B and T cell-mediated immune responses during virus infection and how virus invade adaptive immunity to establish infection.
Week 10: Immunological responses during Influenza virus infection-(part-1); Immunological responses during Influenza virus infection-(part-2); Brief introduction of Arboviral infection.
Week 11: Brief discussion on immunology of bacterial infections including immune responses to extracellular and intracellular bacteria and evasion on antagonistic mechanisms devised by bacteria to evade such responses (part-1); Brief discussion on immunology of bacterial infections including immune responses to extracellular and intracellular bacteria and evasion on antagonistic mechanisms devised by bacteria to evade such responses (part-2) & Immunology of Tuberculosis (some part); Immunology of Tuberculosis (remaining part).
Week 12: Immune responses to parasite and fungal infection; Discussion about Malaria; Discussion about African Sleeping Sickness.

Books and references

1. Essential Immunology: Peter J. Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt; Wiley-Blackwell; any edition;
2. Immunobiology: The immune system in health and disease by Charles Janeway, Paul Travers, Mark Walport, Mark Shlomchik; Garland Science; 5th edition; 2001 or any edition.
3. Kuby Immunology; W. H. Freeman & Company; 6th edition; 2006 or any edition.
4. I will also talk from review and research articles.
5. Infectious Disease: Pathogenesis, Prevention, and Case Studies. Authors: Nandini Shetty, Julian W Tang, Julie Andrews; (2009)

Instructor bio

Prof. Himanshu Kumar

IISER Bhopal
Prof. Himanshu Kumar is heading Laboratory of Immunology and Infectious Diseases, Department of Biological Sciences at the Indian Institute of Sceience Education and Research (IISER) Bhopal. He is working on various aspects of Innate Immunobiology. His major focus is transcriptional and translational level regulation of antiviral innate immune responses during Flu, Dengue or another virus infection.

Prof. Kumar obtained Ph.D. from Graduate School of Medicine, Osaka University, Japan (2008) and awarded as excellent Ph.D. Student of Medical School. He obtained prestigious JSPS Post-doctoral fellowship of Japan. He moved to IISER Bhopal in 2010 as an Independent Principal Investigator to conduct Immunology teaching and research in Innate immunobiology. Prof. Kumar is a recipient of several National and International fellowships. He is also Guest Professor at Immunology Frontier Research Center (IFReC), Osaka University, Japan, a top Immunology Institution in the world. He is heading “International Reviews of Immunology” as an “Editor-in- Chief.” He is also member of prestigious National Acadamy of Science, India (NASI). For more details about his academic and scientific work, please visit to this link: https://home.iiserb.ac.in/~hkumar/index.html

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 29 April 2023 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IISER Bhopal. It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team


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