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Nanobio Technology Enabled Point-of-Care Devices

By Prof. Gorachand Dutta   |   IIT Kharagpur
Learners enrolled: 84
ABOUT THE COURSE:
The course addresses the approach of how to develop the portable, reusable, robust, ultrasensitive and efficient point-of-care (POC) systems that has received significant attention in the healthcare system and analytical process and explains the science behind the detection of analyte of interest at the early stage of diagnosis. Students also will learn the techniques of commercialization of diagnostic devices.

INTENDED AUDIENCE: UG-PG, RS Students, Faculty Members, Industry Professionals, and Medical Professionals.

PREREQUISITES: 10+2 (only basic Sciences)

INDUSTRY SUPPORT:
1) Coromandel International Limited
2) PalmSens
3) Zensor
4) GE Healthcare
5) Greyfalcon Healthcare Private Limited
6) Metrohm
Summary
Course Status : Upcoming
Course Type : Elective
Duration : 8 weeks
Start Date : 20 Feb 2023
End Date : 14 Apr 2023
Exam Date : 30 Apr 2023 IST
Enrollment Ends : 20 Feb 2023
Category :
  • Multidisciplinary
Credit Points : 2
Level : Undergraduate/Postgraduate

Page Visits



Course layout

Week 1: Introduction and basic concept of point-of-care diagnosis,Analytical Chemistry with Biological applications and their mechanistic studies in diagnosis: thermodynamics,chemical kinetics, rate constant.
Week 2: Nanobiomaterials: fundamental concept. Nanomaterials for early stage biomarker detection, synthesis and characterization of Nanoparticles and their use for Biosensors and Biodevices, Biofunctionalization of nanomaterials, beneficial properties of nanomaterials for diagnosis.
Week 3: Basic tools used in diagnostics, Signal amplification chemistry for higher signal-to-background ratios: Redox Cycling amplification methods, electrode surface modification with nanomaterials.
Week 4: Lab-on-a-chip devices for biomedical diagnostics, Multiplex diagnostic microsystem development for rapid quantification, Non-Invasive approach, Printed bioelectronics.
Week 5: New detection systems for POCT and integration of highly sensitive Biosensors to mobile devices: Wash-free detection, label-free detection, Lab-on-Printed circuit board.
Week 6: New detection systems for POCT and integration of highly sensitive Biosensors to mobile devices: Wearable biosensors, smart phone-based platform, disposable self- powered POCT Devices.
Week 7: Device characterization and challenges.
Week 8: Commercialization of biosensor and biodevices,environmental field monitoring, food safety, and security.

Books and references

1) David Wild, The Immunoassay Handbook, Elsevier Science, 4th ed. 2013
2) Joseph Wang, Analytical Electrochemistry, JohnWiley& Sons, Inc. 3rd ed. 2006
3) Peter B. Luppa and Ralf Junker, Point-of-Care Testing: Principle and Clinical Applications, Springer, 1sted. 2018.
4) V. Gubala et al. “Point of Care Diagnostics: Status and Future”, Anal. Chem. 2012, 84, 487–515.
5) M. Yang et al. “Flexible and Disposable Sensing Platforms Based on Newspaper”, ACS Appl. Mater. Interfaces 2016, 8, 34978-34984.
6) X. Xiao et al. “Tackling the Challenges of Enzymatic (Bio) Fuel Cells”, Chem. Rev. 2019, 119, 9509−9558.
7) X, Liu et al. “Smartphones for Cell and Biomolecular Detection”, Ann. Biomed. Eng. 2014, 42, 2205–2217.

Instructor bio

Prof. Gorachand Dutta

IIT Kharagpur
Prof. Gorachand Dutta, PhD is an Assistant Professor with the School of Medical Science and Technology, Indian Institute of Technology Kharagpur. His research interests include the design and characterization of portable biosensors, biodevices and sensor interfaces for miniaturized systems and biomedical applications for point-of-care testing. He received his Ph.D in Biosensor and Electrochemistry from Pusan National University, South Korea, where he developed different class of electrochemical sensors and studied the electrochemical properties of gold, platinum, and palladium based metal electrodes. He completed his Post-doctoral fellowships in the Department of Mechanical Engineering, Michigan State University, USA and Department of Electronic and Electrical Engineering at University of Bath, UK. During his research tenure in USA and UK, Prof. Dutta invented an enzyme- free, disposable miniaturized immunosensor chip using micropatterned electrode and wash-free method for the development of mobile phone-based platforms for fast and simple point-of-care testing of infectious and metabolic disease biomarkers. He has expertise on label-free multichannel electrochemical biosensors, electronically addressable biosensor arrays, aptamer- and DNA-based sensors and surface bio-functionalization. Also his focused areas: (1) integration of biosensors with fuel cell for self-powered biodevices, (2) low-cost, fully integrated biosensor devices using Lab-on-Printed Circuit Board (PCB) approach, (3) enzyme based immunosensor (ELISA), (4) ultra-sensitive biosensors using magnetic bead assays, nanoparticles, CNT, dendrimer, (5) Lab-on-a-Chip devices for biomedical diagnostics, (6) bio-nanotechnology for drug delivery, (7) microfluidics.

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 30 April 2023 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 6 assignments out of the total 8 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Kharagpur. It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team


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