Week 1:
1. Bioenergetics: Understanding the significance in Biological Systems
2. Regulation of Enzyme Activity.
3. Digestion and Absorption of Carbohydrates
4. Glycolysis, alcohol and lactic acid fermentation
5. TCA cycle-I (Biochemistry of TCA cycle)
Week 2:
6. TCA cycle-II (Energetics, Regulation and Anaplerosis)
7. Gluconeogenesis
8. Reciprocal regulation of Glycolysis and gluconeogenesis
9. Cori cycle, glucose-alanine cycle, RLS, feeder glycolysis
10. Hexose Monophosphate Shunt: Steps and Phases
Week 3:
11. Hexose Monophosphate shunt -II (Products and Genetic deficiency of Glucose-6- phosphate dehydrogenase)
12. Glycogenesis
13. Glycogenolysis
14. Regulation of glycogen metabolism
15. Glycogen Storage Disorders
Week 4:
16. Galactose Metabolism and Associated Disorders
17. Fructose Metabolism and Associated Disorders
18. Regulation of Blood Glucose Level
19. Diabetes Mellitus (Types, Diagnosis and Metabolic Alterations)
20. Digestion and absorption of Lipid
Week 5:
21. Lipoprotein metabolism- I (Types and Chylomicron and VLDL Metabolism)
22. Lipoprotein metabolism- II (Metabolism of HDL and LDL)
23. Lipoprotein metabolism- III (Reverse Cholesterol Transport and Lipoproteniemias )
24. β-oxidation of fatty acids-I (Biochemical reactions)
25. β-oxidation of fatty acids-II (Monounsaturated vs poly-unsaturated fatty acids; odd chain vs even chain fatty acids; energetics, regulation and disorders of β-oxidation)
Week 6:
26. β-oxidation of fatty acids-III (α-oxidation, ω-oxidation, peroxisomal β-oxidation and related disorders)
27. Metabolism of Ketone Bodies
28. Biosynthesis of Fatty Acid
29. Overview of biosynthesis of triacylglycerol, phosphoglycerides and sphingolipids
30. Cholesterol Metabolism
Week 7:
31. Digestion and absorption of Proteins
32. Transformation of Amino acids - Transamination and Deamination
33. Ammonia Metabolism -Formation, Transport, Degradation and Mechanism of Toxicity
34. Urea cycle -I (Precursors and Metabolic Cycle)
35. Urea cycle -II (Regulation and associated disorders)
Week 8:
36. Metabolism of Phenylalanine and Phenylketonuria
37. Metabolism of Tyrosine and Associated Disorders
38. Important Products from Tyrosine – I (Catecholamine Synthesis and Degradation)
39. Important Products from Tyrosine – II (Thyroid hormones and Melanin)
40. Metabolism of Tryptophan and Associated Disorders
Week 9:
41. Metabolism of Methionine and Cysteine
42. Metabolism of Glycine (Formation and Biologically Important Products and Associated Disorders)
43. Metabolism of Serine Threonine and Alanine (Including One Carbon metabolism)
44. Metabolism of Branched Chain Amino acids and Associated Disorders
45. Metabolism of Histidine, Proline, Arginine and Lysine and Associated Disorders
Week 10:
46. Heme Metabolism - I (Heme Synthesis and Regulation)
47. Heme Metabolism - II (Porphyrias)
48. Heme Metabolism -III (Heme Degradation, Transport and Bilirubin metabolism)
49. DIsorders of Bilirubin Metabolism (Hyperbilirubinemia and Jaundice)
50. Nucleotide Metabolism – I (Purine Metabolism and regulation)
Week 11:
51. Nucleotide Metabolism – II (Disorders of Purine Metabolism)
52. Nucleotide Metabolism – III (Pyrimidine Metabolism and its associated disorders)
53. Inborn errors of metabolism
54. Integration of Metabolism -I (Cellular and Organ level integration)
55. Integration of Metabolism - II (Starve feed cycle)
Week 12:
56. Integration of Metabolism - III (Metabolic control analysis)
57. Obesity, Metabolic Syndrome and Role of Adipokines
58. Fatty Liver and Alcohol Metabolism
59. Energy metabolism and Nutritional disorders, Protein Energy Malnutrition and Dietary Fibres
60. Metabolism in cancer cells
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