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One And Two Dimensional Nmr Spectroscopy For Chemists

By Prof. N. Suryaprakash   |   IISc Bangalore
Learners enrolled: 559   |  Exam registration: 75
ABOUT THE COURSE :
In this course, I will discuss fundamental concepts of NMR spectroscopy, experimental determination of NMR spectral parameters, their interpretation, selective and broadband homo and Heteronuclear spin decoupling, numerous examples of the analysis of NMR spectra of 1H, 13C and other heteronuclei will be given. The relaxation processes, their measurement and utility in understanding molecular dynamics, the polarization transfer mechanism, the spectral editing techniques, such as, APT, DEPT, INEPT will also be discussed. Two dimensional NMR and the commonly employed experiments, viz., COSY, TOCSY, HSQC, HMQC, HMBC, NOESY, etc will be discussed with number of examples. The practical aspects of one and two dimensional NMR data acquisition and processing will also be highlighted. The solid state NMR, magic angle spinning and cross polarization will also be discussed.

INTENDED AUDIENCE        : It is for chemistry students, pharmaceutical students, biology students

INDUSTRIES  SUPPORT     : The pharma industries, such as, sun pharma, syngine, Biocon, Bal pharma, Aurigine, etc.
Summary
Course Status : Completed
Course Type : Core
Language for course content : English
Duration : 12 weeks
Category :
  • Chemistry
Credit Points : 3
Level : Postgraduate
Start Date : 24 Jul 2023
End Date : 13 Oct 2023
Enrollment Ends : 07 Aug 2023
Exam Registration Ends : 18 Aug 2023
Exam Date : 29 Oct 2023 IST

Note: This exam date is subject to change based on seat availability. You can check final exam date on your hall ticket.


Page Visits



Course layout

Week 1: Conceptual Understanding of NMR Spectroscopy
Week 2: NMR Spectral Parameters I (Chemical Shifts)
Week 3:  NMR Spectral Parameters II (Scalar and Dipolar Couplings)
Week 4: Analysis of 1H NMR spectra with numerous examples
Week 5: Selective and Broadband, Homo and Heteronuclear Decoupling, with examples
Week 6: Analysis of NMR spectra of 13C and many other Heteronuclei
Week 7:  Polarization transfer and spectral editing techniques, APT, DEPT and INEPT
Week 8: Introduction to Multi-Dimensional NMR 
Week 9: Analysis of 2D COSY, TOCSY, HSQC, NOESY spectra with examples
Week 10:Practical Aspects of obtaining high resolution NMR spectra
Week 11: Relaxation processes, their measurement and utility in understanding molecular dynamics
Week 12:NMR in solid state, Magic Angle Spinning and Cross polarization

Books and references

1. A Complete Introduction to Modern NMR Spectroscopy: Robert S Macomber
2. Carbon-13 NMR Spectroscopy, Eberhard Breitmeier and Wolfgang Voelter
3. High Resolution NMR, Theory and Chemical Applications, Edwin D. Becker
4. High Resolution NMR Techniques in Organic Chemistry, Timothy D Claridge
5. NMR Spectroscopy Explained, Neil E Jacobsen

Instructor bio

Prof. N. Suryaprakash

IISc Bangalore
Prof. N. Suryaprakash is currently a CSIR Emeritus Scientist at the Solid State and Structural Chemistry Unit, Indian Institute of Science. Previously he held various positions at IISc including Tatachem Chair Professor, before superannuation as a Professor and Chairman of NMR Research Centre. His academic career has proven to be nothing but exceptional in all aspects and his research achievements have received worldwide recognition, appearing in more than 155 publications in peer-reviewed journals of National and International repute, which include several invited book chapters. His research work is focused on diverse wings of NMR spectroscopy, with a major focus on the manipulation of spin dynamics to design novel experimental techniques to combat inherent challenges encountered in NMR spectroscopy, viz., weak sensitivity, poor resolution, and spectral crowding. He has also designed methods for the rapid acquisition of data, discerning degenerate transitions, and facile extraction of spectral parameters. His designed single and multiple quantum methodologies significantly transformed the chiral analysis of molecules in weakly aligned liquid crystalline media using 1H NMR, a field that remained unchallenged for decades. His research work led to the discovery of three novel water-compatible weak chiral aligning media that surpassed many inherent limitations of enantiomeric differentiation. His group has introduced a number of novel chiral auxiliaries, for enantiodiscrimination of molecules with diverse functionalities, accurate determination of enantiomeric contents, and also for the assignment of their absolute configurations, an area of very high significance in pharmaceutical industries. His innovative NMR approaches for the investigation of hydrogen bonds involving organic fluorine pave the way for the artificial architectural design of macromolecules. His seminal contributions have catapulted the research activities in NMR spectroscopy, structural chemistry, chiral chemistry, and in the area of weak molecular interactions.

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 
29 October 2023 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IISc Bangalore.It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team


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