Human Molecular Genetics

By Prof. S. Ganesh | IIT Kanpur

Learners enrolled: 4514

ABOUT THE COURSE : This is an introductory course designed primarily for students in the undergraduate or master’s programs interested in biomedical research, genetic counseling, medicine, and clinical genetics. This course is expected introduce the rapid advancements in our understanding the role of human genome in health and disease. We would introduce key concepts of inheritance of human traits, pedigree analysis, and chromosome organization. Molecular biology tools used for understanding the genome, gene structure and gene mutations, gene mapping and gene cloning strategies will also be covered. Objectives and outcome of human genome project and the HapMap project will also be discussed at the end.

INTENDED AUDIENCE : Students interested in pursuing research in human molecular genetics.
Medical students and practicing clinicians interested in understanding the principles and complexities of human genetics.
Students interested in careers in genetic counselling and DNA diagnostics.
Scientists working in public health service, counselling centres, and diagnostic laboratories.

PRE- REQUISITES : Participants are expected to have at least class 12 level understanding in genetics.
SUPPORT INDUSTRY : Medical and pharma companies, paramedic clinical centers, educational institutes, and hospitals.

Summary

Course Status :	Completed
Course Type :	Elective
Language for course content :	English
Duration :	4 weeks
Category :	Biological Sciences & Bioengineering Biosciences
Credit Points :	1
Level :	Undergraduate/Postgraduate
Start Date :	23 Jan 2023
End Date :	17 Feb 2023
Enrollment Ends :	06 Feb 2023
Exam Registration Ends :	20 Feb 2023
Exam Date :	26 Mar 2023 IST

Note: This exam date is subject to change based on seat availability. You can check final exam date on your hall ticket.

Page Visits

Course layout

Week 1  : Fundamentals of central dogma (DNA, RNA and proteins; mutations), Chromosome structure and function
(organization; structure-function relationship; chromosome abnormalities).
Week 2  : Genes in pedigree (Mendelian pedigree patterns, complications to pedigree patterns), DNA cloning and hybridization
techniques (vector based cloning; nuclei acid hybridizations; PCR-based DNA analyses)
Week 3  : Mutation and instability of human DNA (mutation and polymorphism; pathogenic mutations, repeat expansions), Molecular
pathology (types of mutations; animal models for human disease)
Week 4  : Identifying human disease genes (functional cloning versus positional cloning; mutation screening), Complex diseases;
The Human Genome and HapMap projects

Books and references

Human Molecular Genetics 4 Tom Strachan, Andrew P. Read Garland Science/Taylor & Francis Group, 2011

Instructor bio

Prof. S. Ganesh

IIT Kanpur

Prof. S. Ganesh teaches biology, genetics and genomics at IIT Kanpur. His research interests include human molecular genetics and neuroscience. He works on genetic forms of neurodegenerative disorders in humans to understand their genetics and disease mechanisms, and to develop therapeutics. He has been serving on the editorial boards of journals, and offers courses on professional and scientific communication at IIT Kanpur. For more information, visit his group’s website: http://home.iitk.ac.in/~sganesh/

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 26 March 2023 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 3 assignments out of the total 4 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Kanpur .It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team

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