Advanced NMR Techniques in Solution and Solid-State

By Prof. N. Suryaprakash | IISc Bangalore

Learners enrolled: 978

About the Course:

In this course, after introducing NMR and the internal interaction parameters, I will discuss some advanced concepts and techniques, such as, relaxation phenomenon and their measurements, NOE and ROE, spin system nomenclature, quantum mechanical analysis of spectra, the polarization transfer mechanism, chemical exchange, pure shift NMR, diffusion ordered spectroscopy, spectra of many heteronuclei, two dimensional NMR and routine 2D experiments, product operator formalism, analysis of 2D spectra. The multiple quantum techniques, the solid state NMR, magic angle spinning and cross polarization, CPMAS techniques and solid state NMR experiments will be discussed in detail.

INTENDED AUDIENCE: Postgraduates and Research Students

PREREQUISITES: Basic knowledge of NMR Spectroscopy and Analysis of Spectra

INDUSTRY SUPPORT: All pharma industries which have NMR facilities

Summary

Course Status :	Completed
Course Type :	Elective
Language for course content :	English
Duration :	12 weeks
Category :	Physics
Credit Points :	3
Level :	Postgraduate
Start Date :	24 Jan 2022
End Date :	15 Apr 2022
Enrollment Ends :	07 Feb 2022
Exam Date :	24 Apr 2022 IST

Note: This exam date is subject to change based on seat availability. You can check final exam date on your hall ticket.

Page Visits

Course layout

Week 1: NMR Introduction, NMR Concepts, Internal Interaction, Chemical Shifts, Internal Interaction, J Couplings, Fourier Transforms and 1D spectra

Week 2: Pulse phase and Receive phase, Evolution of chemical shifts, Evolution of Scalar Couplings, Concept of Relaxation, Relaxation Mechanisms

Week 3: T1 and T2 measurements, Nuclear Overhauser Effect, NOE and ROE, Coupled Spin Systems Nomenclature, Weakly and strongly coupled two spin systems, energy levels and transitions

Week 4: Weakly and strongly coupled two spin systems, energy levels and transitions , Three coupled spin systems, energy levels and transition frequencies, Spin Systems with more than three coupled spins, Quantum Mechanical Analysis of Two Weakly Coupled Spectra, Quantum Mechanical Analysis of AB Spectra

Week 5: Pure Shift NMR, 2D Pure Shift Experiments, Chemical Exchange, Chemical Exchange, Spin Echoes

Week 6: Polarization Transfer Techniques, Polarization Transfer Techniques, 13C NMR , 13C NMR, Spectra of Heteronuclei

Week 7: Spectra of Heteronuclei, Spectra of Heteronuclei, Phase cycling, Pulse Field Gradients, Diffusion Ordered Spectroscopy

Week 8: Diffusion Ordered Spectroscopy, Shaped Pulses spin lock, coherence order, Shaped Pulses spin lock, coherence order, 2D NMR Concepts COSY, TOCSY pulse Sequences

Week 9: "Modified COSY sequences HSQC, NOESY Pulse Sequences Homo and heteronuclear Resolved spectra Analysis of 2D COSY and HSQC spectra 2D Experimental aspects"

Week 10: Product Operators: Evolution of coherences, Product Operators: Evolution of coherences, Product Operators: Evolution of coherences, Concept of Multiple Quantum NMR, Multiple Quantum Spectra of scalar and dipolar coupled spins

Week 11: Difference between Solid state and solution state NMR , Anisotropic NMR parameters: CSA and dipolar couplings, Magic Angle Spinning, Magic Angle Spinning, Cross Polarization

Week 12: CPMAS, High Speed CP, Suppression of Spinning side bands, Selected Experiments in Solid state NMR, Selected Experiments in Solid state NMR

Books and references

1. A Complete Introduction to Modern NMR Spectroscopy: Robert S Macomber

2. Carbon-13 NMR Spectroscopy, Eberhard Breitmeier and Wolfgang Voelter

3. High Resolution NMR, Theory and Chemical Applications, Edwin D. Becker

4. High Resolution NMR Techniques in Organic Chemistry, Timothy D Claridge

5. NMR Spectroscopy Explained, Neil E Jacobsen

And some more books will be introduced as and when required.

Instructor bio

Prof. N. Suryaprakash

IISc Bangalore

N. Suryaprakash, is a professor and the current chairman, NMR Research Centre, Indian Institute of Science. His research work is focused on diverse wings of NMR spectroscopy, with a major focus on the manipulation of spin dynamics to design novel NMR techniques to combat inherent challenging problems of NMR spectroscopy, viz., to achieve sensitivity enhancement, higher resolution, discerning of degenerate transitions and facile extraction of spectral information. His designed single and multiple quantum methodologies significantly transformed chiral analysis of molecules in weakly aligned media using 1H NMR. He has also discovered numerous water compatible weak chiral aligning media that circumvented many inherent limitations of enantiomeric differentiation. His seminal contributions have catapulted research in NMR spectroscopy, structural chemistry, chiral chemistry and in the field of weak molecular interactions

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.

The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).

Date and Time of Exams: 24 April 2022 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.

Registration url: Announcements will be made when the registration form is open for registrations.

The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.

Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.

Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup. It will have the logos of NPTEL and IISc Bangalore.It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team