Classics in Total Synthesis-I

By Prof. Krishna P Kaliappan | IIT Bombay

Learners enrolled: 278

About the course: Some of the classical total synthesis of natural and unnatural products reported between 1950-2000 will be discussed in details. This course will be ideal for 2nd year MSc students and 1st year Ph.D students. This course will be followed by part-II where some important total synthesis of natural products disclosed between 2001 to-date will be discussed.

PRE-REQUISITES: BSc and MSc (1st year)

INTENDED AUDIENCE: Chemistry Masters students/Chemistry PhD students.

INDUSTRY SUPPORT: Most of the pharmaceutical companies.

Summary

Course Status :	Completed
Course Type :	Elective
Language for course content :
Duration :	12 weeks
Category :	Chemistry
Credit Points :	3
Level :	Postgraduate
Start Date :	25 Jul 2022
End Date :	14 Oct 2022
Enrollment Ends :	08 Aug 2022
Exam Date :	29 Oct 2022 IST

Note: This exam date is subject to change based on seat availability. You can check final exam date on your hall ticket.

Page Visits

Course layout

Week 1: General Introduction to Total Synthesis & Syntheses of 3-membered natural products

• Illudin M & C

• FR900848

Week 2: Total Syntheses of four-membered and five-membered natural products

• Cubane

• Endiandric Acids

• Prostaglandins

• Penicillin

Week 3: Total Syntheses of other five-membered natural products and triquinanes

• Thienamycin

• Biotin

• Lactacystin

• Isocomene

• Silphipherfol-6-en-5-one

• Hirsutene

• Capnellene

Week 4: Total Syntheses of triquinanes

• Silphiperfolene

• Modephene

• Silphipherfol-6-en-5-one

• Capnellene

• Hirsutene

• Isocomene

• Ceratopicanol

• Subergorgic acid

• Deoxymagellaninone

• Coriolin

Week 5: Total Syntheses ofsix-membered natural products

• Longifolene

• Carpanone

• Mevinolin

• Gibberellic acid

Week 6: Total Syntheses of alkaloids

• Perhydrohistrionicotoxin

• Strychnine

• Reserpine

Week 7: Total Syntheses of alkaloids

• Yohimbine

• Quinine

• Dendrobine

• Morphine

Week 8: Total Syntheses of alkaloids

• Methylhomosecodaphniphyllate&secodaphnyphillane

• Lysergic acid

• Galanthamine

• Epibatidine

• Swainsonine

Week 9: Total Syntheses of alkaloids and steroids

• Staurosporine

• Manzamine A

• Colchicine

• Progesterone

• Steroids

Week 10: Total Syntheses of steroids & diterpenes

• Estrone

• Taxol

Week 11: Total Syntheses of diterpenes

• Eleutherobin

• Phorbol

• Periplanone

• Discodermolide

Week 12: Total Syntheses of macrocycles and course summary

• Epothilones

• Zaragozic acid C

• Vineomycinone B2

Instructor bio

Prof. Krishna P Kaliappan

IIT Bombay

Prof. Krishna P. Kaliappan is currently a Professor at Department of Chemistry at IIT Bombay. He joined the Department in 2001 as an Assistant Professor and has taught several courses in Organic Chemistry. He also held several administrative positions including Head (Department of Chemistry), Associate Dean (R&D and Dean (Faculty Affairs). He has guided 24 PhD students and currently guiding 15 Ph.D students

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.

The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).

Date and Time of Exams: 29 October 2022 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.

Registration url: Announcements will be made when the registration form is open for registrations.

The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.

Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.

Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Bombay .It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team