One and two dimensional NMR Spectroscopy for chemists

By Prof. N. Suryaprakash   |   IISc Bangalore
Learners enrolled: 773
In this course, I will discuss fundamental concepts of NMR spectroscopy, experimental determination of NMR spectral parameters, their interpretation, selective and broadband homo and Heteronuclear spin decoupling, numerous examples of the analysis of NMR spectra of 1H, 13C and other heteronuclei will be given. The relaxation processes, their measurement and utility in understanding molecular dynamics, the polarization transfer mechanism, the spectral editing techniques, such as, APT, DEPT, INEPT will also be discussed. Two dimensional NMR and the commonly employed experiments, viz., COSY, TOCSY, HSQC, HMQC, HMBC, NOESY, etc will be discussed with number of examples. The practical aspects of one and two dimensional NMR data acquisition and processing will also be highlighted. The solid state NMR, magic angle spinning and cross polarization will also be discussed.

It is for chemistry students, pharmaceutical students, biology students

INDUSTRIES  SUPPORT     : The pharma industries, such as, sun pharma, syngine, Biocon, Bal pharma, Aurigine, etc.
Course Status : Completed
Course Type : Core
Duration : 12 weeks
Category :
  • Chemistry
Credit Points : 3
Level : Postgraduate
Start Date : 25 Jul 2022
End Date : 14 Oct 2022
Enrollment Ends : 08 Aug 2022
Exam Date : 30 Oct 2022 IST

Note: This exam date is subjected to change based on seat availability. You can check final exam date on your hall ticket.

Page Visits

Course layout

Week 1: Conceptual Understanding of NMR Spectroscopy
Week 2: NMR Spectral Parameters I (Chemical Shifts)
Week 3:  NMR Spectral Parameters II (Scalar and Dipolar Couplings)
Week 4: Analysis of 1H NMR spectra with numerous examples
Week 5: Selective and Broadband, Homo and Heteronuclear Decoupling, with examples
Week 6: Analysis of NMR spectra of 13C and many other Heteronuclei
Week 7:  Polarization transfer and spectral editing techniques, APT, DEPT and INEPT
Week 8: Introduction to Multi-Dimensional NMR 
Week 9: Analysis of 2D COSY, TOCSY, HSQC, NOESY spectra with examples
Week 10:Practical Aspects of obtaining high resolution NMR spectra
Week 11: Relaxation processes, their measurement and utility in understanding molecular dynamics
Week 12:NMR in solid state, Magic Angle Spinning and Cross polarization

Books and references

1. A Complete Introduction to Modern NMR Spectroscopy: Robert S Macomber
2. Carbon-13 NMR Spectroscopy, Eberhard Breitmeier and Wolfgang Voelter
3. High Resolution NMR, Theory and Chemical Applications, Edwin D. Becker
4. High Resolution NMR Techniques in Organic Chemistry, Timothy D Claridge
5. NMR Spectroscopy Explained, Neil E Jacobsen

Instructor bio

Prof. N. Suryaprakash

IISc Bangalore
Prof. N. Suryaprakash has been carrying out research in NMR spectroscopic methodological developments and applications. His research achievements have received world wide recognition, appearing in more than 150 publications in peer reviewed journals of National and International repute, which include several invited book chapters and presented the work in more than 140 occasions in various meetings around the world. His research work is focused on diverse wings of NMR spectroscopy, with a major focus on the manipulation of spin dynamics to design novel NMR techniques to combat inherent challenging problems of NMR spectroscopy, viz., to achieve sensitivity enhancement, higher resolution, discerning of degenerate transitions and facile extraction of spectral information. His designed single and multiple quantum methodologies significantly transformed chiral analysis of molecules in weakly aligned media using 1H NMR, a field that remained unchallenged for decades. He has also discovered numerous water compatible weak chiral aligning media that circumvented many inherent limitations of enantiomeric differentiation. He has introduced number of novel chiral auxiliaries, for enantiodiscrimination of molecules with diverse functionalities, accurate determination of enantiopurity and also for the assignment of their absolute configurations. His innovative NMR approaches for investigation of hydrogen bond involving organic fluorine, paves the way for the artificial architectural design of macromolecules. His seminal contributions have catapulted research in NMR spectroscopy, structural chemistry, chiral chemistry and in the field of weak molecular interactions. The quality and innovative character of his work has received several distinctions, viz. G V Bakore Memorial Award of Indian Chemical Society (2015), Tata Chem Chair Professorship (2015) of IISc, President National Magnetic Resonance Society (2015), Adjunct Professorship, Poornaprajna Institute of Scientific Research, Bangalore (2009), Fellowship of the National Academy of Sciences (2005), Sir C.V. Raman Award of Karnataka Government (2001), Young Scientist award of the Karnataka Association for the Advancement of Science (1994). Bruker Young NMR Scientist award (1987). In his highly popular Nation Building and Human Resource Development Activities, he has organized numerous schools and workshops, delivered several hundreds of educative lectures all across the country and abroad to disseminate the knowledge on NMR spectroscopy to college students, young researchers and practicing scientists, which is always greatly enjoyed by all the participants.

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 30 October 2022 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.


Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IISc Bangalore.It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team

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