Week 1: Introductory remarks: Why to study organic synthesis? Historical perspectives of organic synthesis.
Establishing a visual dialogue with the target molecules (imagination, creativity and execution).
Week 2: Retrosynthetic disconnections: The basis for retrosynthetic analysis and terminologies,
Transform based strategies, Substrate/precursor based strategies.
Week 3: Retrosynthetic disconnections: Functional group based strategy
(concept of redundant functionality) and mechanism based strategy (including biomimetic pathways)
Week 4: Retrosynthetic disconnections: Consideration of symmetry elements in synthetic planning;
Local symmetry and pseudo symmetry. Synthesis of symmetrical molecules and concoctive species.
Week 5: Retrosynthetic disconnections: Stereochemical strategies Strategies to create new chiral center/s in a organic molecule
(Resolution, Desymmetrization, Substrate directed approach, Chiron approach, Absolute asymmetric synthesis)
Week 6: Retrosynthetic disconnections: Enantiodivergent and enantioconvergent approaches and case studies (meso trick and C2-trick).
Week 7: Synthetic equivalents: Concepts of synthetic equivalents (formyl/acyl anion, enolate, homoenolate,
Conjunctive species, Linchpin strategy and other related species) and its application in total synthesis.
Week 8: Fragmentation reactions (Overbred intermediates) and molecular rearrangements and its application in organic synthesis
Week 9: Stereochemistry and conformational analysis: Concepts and application of A1,2/A1,3 strain. Baldwin’s cyclization rule.
Week 10: Protecting groups: Selective protection and deprotection of various functional groups and its application in total synthesis
Week 11:Few important name reactions and their applications in organic synthesis
(Several name reactions based on Substitution/displacement strategy, Reductive strategy,
Oxidative strategy, Coupling reactions, Cyclization reactions
Week 12: Total synthesis of few natural products: Longifolene (Corey/ Oppolzer);
Isocomene (Pirrung); Hirsutene and Δ9(12) Capnellene (Curran), Taxol (Nicolaou); Epothiolone A & B (Nicolaou).