Week 1:Introduction, IUPAC nomenclature of organic compounds, Conformation and Configuration, Molecular symmetry elements
Week 2:Molecular point groups, Conformational analysis of alkanes and substituted alkanes, Newman and Saw-horse projection
Week 3: Conformation of cyclic molecules: cyclohexane, mono and disubstituted cyclohexane, cyclohexene, cis- and trans- decalene etc
Isomerism: Stereoisomerism, topicity of ligands and faces, Enantiomers and Diastereomers, asymmetry and dissymmetry, Fisher Projection
Week 5:Stereoisomerism in chiral molecules- optical isomerism, Circular Dichroism (CD) and Optical Rotatory Dispersion (ORD) and their applications, racemization, D/L and R/S nomenclature, meso-compounds etc.
Week 6:Pseudoasymmetry, Stereochemistry of Allenes, substituted Allenes, Atropeisomerism in Biphenyl and Spiro compounds, Geometrical isomerism (cis-/trans- and E/Z notations)
Week 7: Diastereoisomerism in cyclic system- cyclopropane, cyclobutane, cyclohexane, compounds containing C=O, C=N, fused ring compounds
Application of stereochemistry in chemical reactions: Stereoselectivity, Stereospecificity, Regiospecific, Regioselective, Chemoselective reactions Introduction to rate of a reaction, rate determining step etc.
Week 9:Stereochemical aspects of basic organic reactions: SN1, SN2, SNi, NGP, E1 and E2 reaction mechanism, reactions of cyclohexane derivatives
Week 10:Cycloaddition reactions: Diels-Alder reactions, Hydroboration-Oxidation of alkenes,, Baeyer-Villiger Oxidation. Stereochemistry of Aldol condensation, Wittig reaction, Carbonyl addition reaction
Week 11: Stereochemistry of Molecular rearrangements: Pinacol rearrangement, Hoffman, Curtius, Schmidt and Lossen rearrangemnet, Beckmann, Wolff Rearrangement, Cope, Claisen rearrangement
Week 12:Introduction to crystallographic symmetry: 1D symmetry, Concept of 2D symmetry and lattices, notations of symmetry elements, space groups in 2D, 3D lattices, 32 point groups and their notations, crystal systems and Bravais lattices