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Structure, Stereochemistry and Reactivity of Organic Compounds and Intermediates: A Problem-solving Approach

By Prof. Amit Basak   |   IIT Kharagpur
Learners enrolled: 164
Organic chemistry has been synonymous with Chemistry of Carbon Compounds (other than simple salts, oxides and carbides). Besides carbon, organic compounds are mainly made of hydrogen, nitrogen, oxygen, phosphorous and smaller amounts of a few other elements and are thus distinct from other materials. Most of the mass in living things is made up of organic compounds. Unlike various branches of science including physical chemistry where many problems involve determining appropriate equations and solving them, students have a hard time adjusting to organic chemistry, which has its own logic that cannot be mastered by going through in bits and pieces. Only after having gone through the various classes of organic molecules and their reactive sites, one can start seeing the correlation between the different classes of organic reactions and their mechanistic details. The purpose of this course entitled Structure, Stereochemistry and Reactivity of Organic Compounds and Intermediates: A Problem-solving Approach is to provide a solid foundation on organic chemistry through a problem solving technique which centers on structure, stereochemistry and a mechanistic approach. Completion of this course enables the students to arrive at the realization that organic chemistry can not only be mastered, but is enjoyable as well.

INTENDED AUDIENCE
Chemistry, Biochemistry, Biotechnology, Pharmacy undergraduate students
PREREQUISITES : Preferably taken a basic Organic Chemistry course at the first UG level and also the Stereochemistry course by NPTEL
INDUSTRIES  SUPPORT     : Speciality Chemical and Pharmaceutical Companies
Summary
Course Status : Upcoming
Course Type : Core
Duration : 8 weeks
Start Date : 24 Jan 2022
End Date : 18 Mar 2022
Exam Date : 27 Mar 2022 IST
Category :
  • Chemistry
Credit Points : 2
Level : Undergraduate



Course layout

Week 1:Structure and stereochemistry : A brief introduction to different types of chirality: Tetrahedral, Axial, Planar, Helical including assignment of absolute configuration. Pseudoasymmetry and Reflection Invariance Issue.
Week 2:Conformations of saturated fused ring systems (decalins), heterocycles (sugars) and polynuclear hydrocarbons (perhydrophenanthrene, anthracene and steroid)
Week 3: 3D Structure determination of Chiral Molecules: Chiroptical properties: ORD and CD; Cotton effect; axial haloketone and octant rules; determination of conformation and configuration
Week 4:Stereoelectronic control on conformation and reactivity; Intramolecular Cyclizations: Baldwin rules
Week 5:Organic Intermediates : Alkynes, Arynes, Allenes, Ketenes and methods of their generation, structures and reactivity
Week 6:Organic Intermediates :  C-Radicals: structure and stability; classification: nucleophilic, electrophilic and captodative; inter and intramolecular additions to C=C, CΞC. CΞN, C=NOH; Umpolung reactions; Barton reaction
Week 7: Asymmetric Reactions of Carbonyls : Stereochemistry of nucleophilic addition to carbonyls and unsaturated carbonyls; Asymmetric alkylation
Week 8:Asymmetric Reactions of Carbonyls :  Aldol reactions: Zimmerman-Traxler model, chiral auxiliary and catalytic approaches

Books and references

Organic Chemistry: Jonathan Clayden, Nick Greeves, et al
Organic Chemistry: John E. McMurry
Organic Chemistry: Paula Bruice
Stereochemistry of Organic Compounds : D. Nasipuri

Instructor bio

Prof. Amit Basak

IIT Kharagpur
Prof. Amit Basak offering this course at the first year level at IIT Kharagpur for many years. Before that, I had taught UG students of Presidency University for more than 10 years. Due to my interaction with Sir Prof J. Baldwin (my PhD supervisor at Oxford) and Prof Talapatra ( PhD supervisor, both of whom are renowned stereochemists, my interest in teaching stereochemistry at UG and PG level grew up immensely

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 27 March 2022 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 6 assignments out of the total 8 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Kharagpur .It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team


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