Week 1:Structure and stereochemistry : A brief introduction to different types of chirality: Tetrahedral, Axial, Planar, Helical including assignment of absolute configuration. Pseudoasymmetry and Reflection Invariance Issue.
Week 2:Conformations of saturated fused ring systems (decalins), heterocycles (sugars) and polynuclear hydrocarbons (perhydrophenanthrene, anthracene and steroid)
Week 3: 3D Structure determination of Chiral Molecules: Chiroptical properties: ORD and CD; Cotton effect; axial haloketone and octant rules; determination of conformation and configuration
Stereoelectronic control on conformation and reactivity; Intramolecular Cyclizations: Baldwin rules
Week 5:Organic Intermediates : Alkynes, Arynes, Allenes, Ketenes and methods of their generation, structures and reactivity
Week 6:Organic Intermediates : C-Radicals: structure and stability; classification: nucleophilic, electrophilic and captodative; inter and intramolecular additions to C=C, CΞC. CΞN, C=NOH; Umpolung reactions; Barton reaction
Week 7: Asymmetric Reactions of Carbonyls : Stereochemistry of nucleophilic addition to carbonyls and unsaturated carbonyls; Asymmetric alkylation
Week 8:Asymmetric Reactions of Carbonyls : Aldol reactions: Zimmerman-Traxler model, chiral auxiliary and catalytic approaches