Bioreactor Design and Analysis

By Prof. Smita Srivastava   |   IIT Madras
Learners enrolled: 1479
This is a core course suitable for undergraduate or postgraduate students interested in the area of bioprocess engineering or biological engineering. The course introduces the student to design principles of batch, fed-batch and continuous bioreactors. Mass and heat transfer requirements for a given fermentation system will be discussed. The student will also be able to identify suitable criterion for the scale-up of bioprocesses and characterize non-ideality in bioreactors, if present.

INTENDED AUDIENCE: Students with a background in Biotechnology/ Bioprocess Engineering/Biochemical Engineering/Chemical Engineering
PREREQUISITES: The student is expected to have a basic knowledge of mathematics Prerequisite courses can be Material and Energy Balances, Biological Rate processes, Enzyme science and Engineering
INDUSTRIES  SUPPORT: All biotechnology based/fermentation Industries. SMEs/Companies dealing with production of compounds via microbial/plant/animal cell fermentations
Course Status : Completed
Course Type : Core
Duration : 8 weeks
Category :
  • Biological Sciences & Bioengineering
  • Bioprocesses
Credit Points : 2
Level : Undergraduate/Postgraduate
Start Date : 24 Jan 2022
End Date : 18 Mar 2022
Enrollment Ends : 07 Feb 2022
Exam Date : 27 Mar 2022 IST

Note: This exam date is subjected to change based on seat availability. You can check final exam date on your hall ticket.

Page Visits

Course layout

Week 1: Introduction to the course
Week 2: Design of batch bioreactors  
Week 3: Design of fed-batch bioreactors
Week 4: Design of continuous mode of bioreactors
Week 5: Mass transfer in bioreactors, Rheology of fermentation broths,  Heterogeneous reactions in bioprocesses
Week 6: Heterogeneous reactions in bioprocesses (contd.), Heat transfer in bioreactors
Week 7: Heat transfer in bioreactors (contd.) Scale-up of bioreactors: criteria for scale-up, scale-up parameters
Week 8: Scale-up of bioreactors (contd.), Non-ideal reactors: design and analysis

Books and references

1. Michael L. Shuler and Fikret Kargi, Bioprocess Engineering: Basic Concepts, Prentice Hall, 1992
2. James M. Lee, Biochemical Engineering, Prentice Hall, 1992
3. Pauline Doran, Bioprocess Engineering Principles, 2nd Edition, Academic Press 2012
4. James E. Bailey and David F. Ollis, Biochemical Engineering Fundamentals, McGraw Hill 1986.
5. S.Liu, Bioprocess Engineering: Kinetics, Biosystems, Sustainability, and Reactor Design, Elsevier, 2016
6. Octave Levenspiel, Chemical Reaction Engineering, Wiley 2016.

Instructor bio

Prof. Smita Srivastava

IIT Madras
Prof. Smita Srivastava has expertise in the application of Chemical and Biochemical Engineering principles for the development of large-scale sustainable bioprocesses for commercial production of speciality chemicals. She is an Associate Professor in the Department of Biotechnology at IIT Madras. She has more than 10 years of Teaching experience in which she has taught many theory and lab courses related to the field of Bioprocess engineering, including Bioreactor Design and Analysis, Bioprocess Modeling and Simulation, Plant Cell bioprocessing, Bioreaction Engineering Lab and Bioprocess Engineering Lab, for the B.Tech/M.Tech/M.S/PhD students of the Institute. Her research experience in bioprocess engineering has resulted in 28 peer-reviewed international journal publications as first/corresponding author, 5 book chapters, 5 patent applications and several different international/national conference presentations in the broad area of bioprocess development and optimization.

To promote research in a specialized field like Plant Cell Bioprocess, she formulated and offered a new course in 2012 on Plant Cell Bioprocessing (as a professional elective) for the undergraduates and postgraduate students of IIT Madras. This course is also offered as an NPTEL course now. Dr. Smita is also affiliated to the Teaching and Learning Center at IIT Madras as a core faculty member, where she rendered her services as coordinator and resource person in various faculty development programmes/workshops and teaching assistant training programmes

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 27 March 2022 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.


Average assignment score = 25% of average of best 6 assignments out of the total 8 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Madras .It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team

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