Cell Biology: Cellular organization, division and processes

By Prof. Shikha Laloraya | IISc Bangalore

Learners enrolled: 7085

This course focuses on cell organization, and the molecules and intracellular processes crucial for life and inheritance. A particular emphasis is on DNA transactions such as chromosome organization, replication, chromosome segregation, etc. Some examples of key discoveries in the field of cell cycle regulation, chromatin organization, and the dynamic processes and molecular machines involved in cell division will be discussed in detail. Other topics include Nuclear organization, Mitosis and Meiosis and cell death. In addition, cellular diversity will be discussed including selected specialized eukaryotic cells and their functions, cancer cells-how controls go wrong, and stem cells.
This course includes 2 modules of 10 lectures each. It is intended for graduate students mainly M.Sc. students (or 1st year Ph.D. students). Final year B.Sc. students may also find it useful.

INTENDED AUDIENCE : Biology, Chemistry.

PREREQUISITES : Basic Molecular Biology, Genetics and Biochemistry. Especially basic structure and function of biomolecules including enzymes.

INDUSTRIES SUPPORT : None

Summary

Course Status :	Completed
Course Type :	Core
Language for course content :	English
Duration :	8 weeks
Category :	Biological Sciences & Bioengineering Biosciences
Credit Points :	2
Level :	Undergraduate/Postgraduate
Start Date :	24 Jan 2022
End Date :	18 Mar 2022
Enrollment Ends :	07 Feb 2022
Exam Date :	27 Mar 2022 IST

Note: This exam date is subject to change based on seat availability. You can check final exam date on your hall ticket.

Page Visits

Course layout

Week 1: Lecture 1- Cell components and organization; macromolecules, membranes, organelles, and processes.
Lecture 2- DNA: The genetic material; Cell Cycle.
Lecture 3- Regulation of the Cell Cycle.

Week 2: Lecture 4- S-phase: DNA Replication and its regulation. Repair and recombination.
Lecture 5- Checkpoints: DNA Damage and DNA Replication checkpoints.

Week 3: Lecture 6- Chromosome reorganization during mitosis; The centrosome duplication cycle.
Lecture 7- The microtubule cytoskeleton; Spindle organization, assembly and dynamics.
Lecture 8- Molecular motors; Role of motor proteins in mitosis.

Week 4: Lecture 9- Mitotic checkpoints; Chromosome segregation and cell division.
Lecture 10- Meiosis

Week 5: Lecture 11- Cell death, aging and senescence.
Lecture 12- Chromatin organization
Lecture 13- SMC proteins and chromosome organization

Week 6: Lecture 14- The cohesin complex and its functions.
Lecture 15- Nuclear organization

Week 7: Lecture 16- Cell diversity and properties of specialized cells.
Lecture 17- The Cancer Cell
Lecture 18- Stem cells

Week 8: Lecture 19- Nerve cells
Lecture 20- The Plant Cell

Books and references

Alberts, et al. Molecular Biology of the Cell.

Lodish, et al. Molecular Cell Biology.

Instructor bio

Prof. Shikha Laloraya

IISc Bangalore

Work experience:I am a Professor of Biochemistry, I.I.Sc. I also was Associate Professor and Assistant Professor of Biochemistry, and a Wellcome Trust International Senior Research Fellow in Biomedical Science in India, at I.I.Sc. Academic background:I did my Ph.D. in Oncology, from the University of Wisconsin-Madison, U.S.A. and post-doctoral research at the Carnegie Institution of Washington, Dept. of Embryology, and the Howard Hughes Medical Institutes, in Baltimore, U.S.A. I obtained an M.Sc. degree from the Centre for Biotechnology, Jawaharlal Nehru University, and also studied Life Sciences at the School of Life Sciences, Devi Ahilya Vishwavidyalaya. I did my B.Sc. from Devi Ahilya Vishwavidyalaya, Indore. Selected Awards: -The Wellcome Trust International Senior Research Fellowship in Biomedical Science in India, The Wellcome Trust, UK. 2001-2006 -Howard Hughes Medical Institute Research Associate at the Carnegie Institution, Baltimore, MD, USA. 1997-1999 -The Wisconsin Power and Light Foundation Fellowship in Cancer Research, Mc Ardle Laboratory for Cancer Research, UW-Madison, USA. -The Ravindra Nath Tagore Janm Shatabdi Gold Medal for First Rank among Bachelors degree candidates in all disciplines in the university, Devi Ahilya University, Indore, India -The Prerna Club Gold Medal for First Rank among women in B.Sc., Devi Ahilya University, Indore, India -Chintamani award for First Rank in the University for B.Sc., Devi Ahilya University, Indore, India. My general expertise is Molecular Genetics, Cell Biology and Biochemistry and my current research interests are Chromosome organization, Gene expression, post-translational modfications of proteins, Mitosis, and Cell Cycle. More information at: https://www.researchgate.net/profile/Shikha_Laloraya https://biochem.iisc.ac.in/shikha-laloraya.php

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 27 March 2022 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 6 assignments out of the total 8 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IISc Bangalore.It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team

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