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Metal Mediated Synthesis-I

By Prof. D. Maiti   |   IIT Bombay
Learners enrolled: 624
The course covers an advance level of organometallic chemistry. Recent development of cross coupling reactions and their applications in organic synthesis, starting from small molecule to naturally and pharmaceutically important compounds, has been described in the prescribed course. In this course, a brief overview about the carbine chemistry and oxidative cyclization is also portrayed.


INTENDED AUDIENCE: Students, PhD scholars, teachers, industry.
PREREQUISITES:  Advance Organic and Inorganic Chemistry.
INDUSTRY SUPPORT:  All Pharmaceutical Industries.
Summary
Course Status : Ongoing
Course Type : Elective
Duration : 4 weeks
Start Date : 26 Jul 2021
End Date : 20 Aug 2021
Exam Date : 26 Sep 2021 IST
Enrollment Ends : 09 Aug 2021
Category :
  • Chemistry
Credit Points : 1
Level : Undergraduate/Postgraduate



Course layout

Week 1 :

Lecture 1:  Assymetric Hydrogenation
Lecture 2:  Transition metal carbenes,Fischer and Schrock carbenes
Lecture 3:  Olefin metathesis
Lecture 4:  Alkyne metathesis
Lecture 5:  Cyclopropanation reaction

Week 2 : 

Lecture 6:  Catalytic cyclopropanation reaction,Introduction to cross coupling reaction
Lecture 7:  Kumada Coupling reaction
Lecture 8:  Suzuki coupling reaction
Lecture 9:  Stille coupling reaction
Lecture 10:Assymetric Suzuki coupling reaction

Week 3 : 

Lecture 11: Sonogashira coupling reaction
Lecture 12: Heck coupling reaction
Lecture 13: Assymetric Heck reaction,Introduction to Buchwald-Hartwig coupling reaction
Lecture 14: Buchwald-Hartwig coupling reaction
Lecture 15: Role of Ligands  its influence in Buchwald-Hartwig coupling reaction

Week 4 : 

Lecture 16: Oxidative cyclization process
Lecture 17: Application of oxidative cyclization in natural product synthesis
Lecture 18: Synthesis of reactive metallacycle intermediate via-Beta-abstraction and their applications
Lecture 19: Kulinkovich Reaction and its mechanism
Lecture 20: Pauson–Khand reaction 

Books and references

Organometallic Chemistry by Gupta, BD and Elias AJ,Hartwig JF,Crabtree RH,Elschenbroich and Salzer,Robin Whyman.

Instructor bio

Prof. D. Maiti

IIT Bombay
I am Dr. Debabrata Maiti, Associate Professor at IIT Bombay. I have completed PhD from Johns Hopkins University with Prof. Kenneth D. Karlin in bioinorganic chemistry. Then I moved to MIT where I did my Post-doctoral research with Prof. Steven Buchwald. I have started independent carrier at IIT Bombay in 2011 and since then involved actively in teaching bio-inorganic chemistry and organometallic chemistry. Our group is also active in research areas of bio-inorganic chemistry and C-H activation.

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 26 September 2021 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 3 assignments out of the total 4 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100
Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Bombay .It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team


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