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Organic Chemistry in Biology and Drug Development

By Prof. Amit Basak   |   IIT Kharagpur
Learners enrolled: 860
In the biosphere, the chemistry must be considered in the context of the cell, or an organ, or even a whole organism. That makes mimicking of biological processes to be extremely challenging as the reaction needs to be performed with perfect orthogonality to other functional entities present in a biological system. Today, with the advancement of various spectroscopic and molecular biology techniques and with a better understanding of chemical principles, functions of various bio molecules have been unravelled which has paved the way for development of newer drugs. The present course is an attempt to bridge the gap in our understanding of biological systems and processes at the molecular and functional level. The course first introduces the various kinds of bio molecules, macro to medium size to small, their structures and functions followed by molecular engineering to manipulate their activity and biosynthesis. That creates a perfect platform for the next module on drug design and discovery

INTENDED AUDIENCE   :  Chemistry, Biochemistry, Chemical Biology, Pharmacy Students/faculty
PREREQUISITES     :  Basic Organic Chemistry
Summary
Course Status : Upcoming
Course Type : Elective
Duration : 12 weeks
Start Date : 26 Jul 2021
End Date : 15 Oct 2021
Exam Date : 23 Oct 2021 IST
Enrollment Ends : 02 Aug 2021
Category :
  • Chemistry
Credit Points : 3
Level : Postgraduate



Course layout

Week 1 : Introduction,Amino Acids,Peptides and proteins
Week 2 : Peptides and proteins (contd.)
Week 3 : Peptides and proteins (contd.)
Week 4 : Proteins as biological catalyst,Concept of inhibition
Week 5 : Nucleic acids,
Week 6 : Metabolism,Synthetic biology,Molecular Biology
Week 7 : Chemistry of cofactors/coenzymes
Week 8 : Principle of drug design,Modern day drug discovery
Week 9 : Chemistry of diseases and Drug development
Week 10: Chemistry of diseases and Drug development (contd.)
Week 11: Proton pump inhibitors,Gene replacement and delivery
Week 12: Revision and Problem solving

Books and references

Biochemistry by Voet and Voet
Drug Design by R. Silverman
Medicinal Chemistry by G. L. Patrick

Instructor bio

Prof. Amit Basak

IIT Kharagpur
Prof. Amit Basak offering this course at the first year level at IIT Kharagpur for many years. Before that, I had taught UG students of Presidency University for more than 10 years. Due to my interaction with Sir Prof J. Baldwin (my PhD supervisor at Oxford) and Prof Talapatra ( PhD supervisor, both of whom are renowned stereochemists, my interest in teaching stereochemistry at UG and PG level grew up immensely

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 23 October 2021 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Kharagpur .It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team


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