Week 1:Lecture 1: Introduction to organic synthesis, importance of selectivity and basics of oxidation of alcohols and development of sulfur based oxidations: Swern oxidation and related concepts
Lecture 2: Continuation of Swern oxidation and the utility of intermediates derived from Swern oxidation including Pummerer intermediates Lecture 3. Oxidations using selenium compounds such as SeO2 and organoselenium compounds
Week 2:Lectures 4 and 5: Dess-Martin, IBX and related hypervalent iodine based oxidations
Lecture 6: Silver carbonate/celite, Prevost reactions and its modern variation. Microbial oxidations such as Pseudomonas Putida etc.
Week 3: Lecture 7: Oxidations with RuO4 and other Transition metal catalysed oxidations
Lecture 8: Tamao-Fleming Oxidation
Lecture 9: Oxidations with Dimethyl dioxirane (DMDO) and 2-sulfonyloxaziridines and chiral versions
Lecture 10:Oxidations at unfunctionalised carbons, Photosensitized oxidations
Week 4: Lectures 11-14: Reduction of Carbonyl compounds with Boron and Aluminium based reagents such as Luche Reduction, NaCN(BH3), DIBAL, Red-Al, L-and K-Selectrides, Superhydrides and associated selectivities.
Week 5: Lecture 15: Low Valent Titanium species and Microbial reductions (NADH model etc.)
Lecture 16: Dissolving Metal Reductions
Lecture 17: Reduction with Silanes
Week 6: Lectures 18 and 19: Sharpless epoxidation and synthetic utility of the chiral epoxy alcohols
Lecture 20: Katsuki-Jacobsen epoxidation and mechanistic details
Lectures 21 : OsO4 based and related Sharpless Asymmetric Dihydroxylation
Week 7: Lecture 22: Corey’s oxazaborilidines in asymmetric reductions
Lecture 23: Noyori’s Ruthenium catalysed reduction of ketones
Lecture 24: Asymmetric Hydrogenations with BINAP
Week 8: Lecture 25: C-C Bond formation via Carbanions alpha to electron withdrawing groups
Lecture 26: Boron and Silicon Enolates: Formation and Use in C-C Bond Formation
Lecture 27: Imines in C-C Bond Formation
Lecture 28: Simmons-Smith Cyclopropanation in Organic Synthesis
Week 9: Lectures 29-32: Use of Allyl Boron, Allyl and Vinyl Silanes and Allyl Tin compounds in C-C Bond Formation
Week 10: Lecture 33: Introduction to SAMP and RAMP chiral ligands for asymmetric C-C bond formation
Lecture 34: Introduction to Oppolzer’s Sultam based chiral ligands and their reactions for organic synthesis
Lectures 35 and 36: Evans’ Oxazolidinone for asymmetric synthesis
Week 11: Lectures 37 and 38: Synthesis of selected natural products using above discussed methods of oxidation, reduction and C-C Bond formations
Week 12:Lectures 39 and 40: Synthesis of selected natural products using above discussed methods of oxidation, reduction and C-C Bond formations
Teaching Assistant
Dr
Padma Shree Vankar
I work as Research Adviser in Bombay Textile Research Association (BTRA), Mumbai, currently. I did Ph.D from Chemistry Department, IIT Kanpur in 1987 in the area of Synthetic organic chemistry and worked at FEAT Laboratory, IIT Kanpur as Principal Research Scientist from 1996 to 2017. I have been closely working with Chemical and Textile Industries thereafter. I am the TA for the course entitled- Essentials of Oxidation, Reduction and C-C bond formation: Applications in Organic synthesis.
My email id is padma.vankar@gmail.com
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