Fundamentals of Protein Chemistry

By Prof. Swagata Dasgupta   |   IIT Kharagpur
Learners enrolled: 429
The course provides an in-depth study into protein structure and function. Building up from an understanding of amino acids and the peptide bond that form the basics of protein structure, protein folding and denaturation will be studied followed by the techniques used for protein isolation and characterization. The importance of metalloproteins and motor proteins will be followed by a discussion on membrane proteins and transport. Important aspects of enzymes, their mechanisms, kinetics and inhibition will be looked into with specific examples. The discussion on protein interactions will cover protein-ligand and protein-protein interactions. Finally some special topics in Protein Chemistry will be discussed relevant to current literature.

INTENDED AUDIENCE  : Undergraduate and Graduate students
PREREQUISITES  :  Biochemistry
Course Status : Upcoming
Course Type : Core
Duration : 12 weeks
Start Date : 26 Jul 2021
End Date : 15 Oct 2021
Exam Date : 24 Oct 2021
Enrollment Ends : 02 Aug 2021
Category :
  • Biological Sciences & Bioengineering
  • Biosciences
Credit Points : 3
Level : Undergraduate/Postgraduate

Course layout

Week 1: Amino acids and the Peptide Bond 

Week 2: Protein Architecture 

Week 3: Protein Folding and Denaturation 

Week 4: Protein isolation and characterization 

Week 5: Protein-ligand interactions  

Week 6: Membrane Proteins and Transport 

Week 7: Enzymes and Enzyme mechanisms 

Week 8: Enzyme kinetics and Enzyme inhibition 

Week 9: Metalloproteins and Motor Proteins  

Week 10: Protein-Protein interactions 

Week 11: Protein Structure analysis 

Week 12: Special Topics in Protein Chemistry 


Books and references

1. Introduction to Protein Structure: Second Edition by Carl Branden and John Tooze 

2. Proteins: Structures and Molecular Properties by Thomas E. Creighton 

3. Physical Biochemistry by K.E.van Holde, C. Johnson, P. S. Ho 

4. Structure in Protein Chemistry by Jack Kyte

5. Principles of Biochemistry, 6th Edition by Albert L Lehninger; David L Nelson; Michael M Cox

6. Introduction to Proteins: Structure, Function, and Motion, 2nd Edition (2018) by Amit Kessel & Nir Ben-Tal

7. Biochemistry, 9th Edition (2019) by Lubert Stryer; Jeremy Berg; John Tymoczko; Gregory Gatto


Instructor bio

Prof. Swagata Dasgupta

IIT Kharagpur
Professor Swagata Dasgupta completed her B.Sc. (Hons) in Chemistry from Presidency College, Kolkata and her M.Sc. from IIT Kanpur. After a Post M.Sc. in Bioscience she obtained her Ph.D. from Rensselaer Polytechnic Institute, USA. She then joined IIT Kharagpur and initiated research in Protein Chemistry in the Department of Chemistry at IIT Kharagpur. Her areas of interest are protein–protein and protein-small molecule interactions and protein structure analyses. Professor Swagata Dasgupta has contributed to teaching and research at IIT Kharagpur for the past 25 years. She has over 150 publications in peer reviewed journals with over 3800 citations. Her interdisciplinary research activities in biophysical chemistry have led to several ongoing research collaborations. Over the years her laboratory has become an active center of research with generous support from funding agencies. Graduate students from her laboratory are well-placed both in India and abroad. Her teaching contributions range from classroom teaching, web-course development, introduction of new courses and teaching laboratories, development of curriculum, and initiation of research in a new area in the department. A video course in Biochemistry under the aegis of the National Program on Technology Enhanced Learning funded by the Ministry of Human Resource Development has received overwhelming response worldwide by both students and educators. She has given many popular lectures to young scholars and students and has been invited to inspire young women to science. She has served on many Interview boards and is also actively involved as a reviewer in many journals. Her contributions have been recognized by the award of the Bronze medal by the Chemical Research Society of India (CRSI) for 2016. She also received the Darshan Ranganathan Memorial Lecture Award of CRSI in 2013. She was inducted as a Fellow of the West Bengal Academy of Science and Technology, India in 2014. She is an elected Member of the National Academy of Science, Allahabad since 2013 and a Fellow of the Indian Academy of Sciences, Bangalore since 2018.

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 24 October 2021 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.


Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Kharagpur .It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team

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