Biostatistics and Design of experiments

By Prof. Mukesh Doble   |   IIT Madras
Learners enrolled: 2139
Biostatistics is the application of statistics to different topics in biology including medicine, pharmacy, public health science, agriculture and fishery. It involves the analysis of data from experiments; its interpretation and drawing conclusion from the results. It is very relevant to all UG and PG level degree programmes majoring in Biotechnology and allied fields as well as practicing scientists. It involves the application of statistical theory to real-world problems, the practice of designing and conducting biomedical experiments and clinical trials. Design of experiments is planning experimental strategy, screening a large number of parameters and selecting the important ones, determining the minimum number of experiments and deciding on the mode and manner in which experiment have to be conducted. The course encompasses topics such as distribution of data, sample size, tests of significance, data reduction, regression analysis, comparison of performance of drugs in clinical trials, design of experiments, screening and second order designs.

INTENDED AUDIENCE  : UG/PG Biotech programmes (core or elective) and research scientists in biotechnology, clinical trials, agriculture etc and allied fields 
PREREQUISITES Basics of probability and statistics 
INDUSTRY SUPPORT Biopharma, Agriculture, fisheries and Biotechnology companies.
Course Status : Ongoing
Course Type : Elective
Duration : 8 weeks
Start Date : 18 Jan 2021
End Date : 12 Mar 2021
Exam Date : 21 Mar 2021
Enrollment Ends : 01 Feb 2021
Category :
  • Biological Sciences & Bioengineering
Level : Undergraduate/Postgraduate

Course layout

Module 1
Experimental design strategy
Data types/Binomial Distribution
Poisson Distribution
Normal Distribution

Module 2
Standardized Normal Distribution/ t distribution
t distribution/confidence interval
Statistical tests
t- tests
t- tests – continued

Module 3

t- tests – continued
F- tests
F- tests –continued

Module 4

Module 5

c2 distribution/test
c2 distribution/test –continued
c2 test
Weibull distribution

Module 6
Weibull distribution-contniued
Weibull distribution-continued
Nonparametric tests
Nonparametric tests/Homogeneity of variance/Beta distribution
Exponential / Hypergeometric distributions

Module 7
Hypergeometric/Log normal distributions
Design of Experiments (DOE) – Introduction
Factorial design
Full Factorial design
Fractional Factorial design

Module 8
Other designs
Second order designs
Second order designs-continued
Regression Analysis Control Charts

Books and references


Instructor bio

Prof. Mukesh Doble

IIT Madras
Mukesh Doble: Professor at the department of Biotechnology at IIT Madras. Has previously worked in Imperial chemical Industries(ICI) and General Electric(GE) for 20 years . Areas of research are Biomaterials, Biopolymers and Drug design. Published 270 papers and 10 books and filed 10 patents (including two US). Has delivered on line video courses in Downstream processes and Biostatistics.

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 21 March 2021 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.


Average assignment score = 25% of average of best 6 assignments out of the total 8 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Madras .It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team

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