Introduction to mechanobiology

By Prof. Shamik Sen   |   IIT Bombay
Mechanobiology is an upcoming interdisciplinary field of science where concepts of mechanics, biology and engineering are combined to understand the basics of different cellular processes ranging from cell division to cell differentiation and death.

INTENDED AUDIENCE :  Biotech/Biosciences/Bioengineering/Physics/Mechanical Engineering/Chemical Engineering
PRE-REQUISITES B.Sc/B. Tech: Biotech/Biosciences/Bioengineering MSc/M.Tech: Biotech/Biosciences/Bioengineering
INDUSTRY SUPPORT  Industries that will recognize this course Academic Institutes, Startups working in the area of tissue engineering

Learners enrolled: 684


Course Status : Ongoing
Course Type : Core
Duration : 8 weeks
Start Date : 14 Sep 2020
End Date : 06 Nov 2020
Exam Date : 18 Dec 2020
Enrollment Ends : 25 Sep 2020
Category :
  • Biological Sciences & Bioengineering
  • Bioengineering
  • Level : Undergraduate


    Week 1
    Lecture 1: Need to study Mechanobiology
    Lecture 2: Cell as a Tent, individual components
    Lecture 3: Cell-ECM crosstalk
    Lecture 4: ECM proteins: Collagen
    Lecture 5: Measuring properties of collagen networks

    Week 2
    Lecture 6:   Properties of collagen networks
    Lecture 7:   Rheology
    Lecture 8:   Rheology of biopolymer networks
    Lecture 9:   Atomic Force Microscopy (AFM)
    Lecture 10: Design of protein constructs for AFM

    Week 3
    Lecture 11: Protein unfolding using AFM
    Lecture 12: Protein unfolding using AFM
    Lecture 13: Focal adhesions: focal adhesion proteins
    Lecture 14: Focal adhesion organization
    Lecture 15: Focal adhesions: role of forces

    Week 4
    Lecture 16: Cytoskeleton: Actin
    Lecture 17: Force-velocity relationships of actin networks
    Lecture 18: Mesenchymal cell migration
    Lecture 19: Actin dynamics during mesenchymal migration
    Lecture 20: Actin dynamics during mesenchymal migration

    Week 5
    Lecture 21: Adhesion Independent Migration
    Lecture 22: Adhesion Independent & Collective Cell Migration
    Lecture 23: Collective Cell Migration
    Lecture 24: Mechanobiology of Stem Cell Fate - I
    Lecture 25: Mechanobiology of Stem Cell Fate - II

    Week 6
    Lecture 26: Mechanobiology of Stem Cell Fate - III
    Lecture 27: Mechanobiology of Diseases: Cancer I
    Lecture 28: Mechanobiology of Diseases: Cancer II
    Lecture 29: Mechanobiology of Diseases: Cancer III
    Lecture 30: Mechanobiology of Diseases: Atherosclerosis & Hypertension

    Week 7
    Lecture 31: Mechanobiology of Diseases: Muscular Dystrophy
    Lecture 32: Nuclear Mechanotransduction: LINC complex
    Lecture 33: Nuclear Mechanotransduction: LINC complex in cell migration
    Lecture 34: Nuclear Mechanotransduction: Gene regulation
    Lecture 35: Mechanical Forces & DNA damage

    Week 8
    Lecture 36: Techniques in Mechanobiology: Hydrogels
    Lecture 37: Techniques in Mechanobiology: AFM
    Lecture 38: Techniques in Mechanobiology: Traction Force Microscopy, Trypson Deadhesion
                        & Laser Ablation
    Lecture 39: Techniques in Mechanobiology: Microfabrication
    Lecture 40: Techniques in Mechanobiology: FRE


    1.Introduction to Cell mechanics and Mechanobiology, Christopher. R. Jacobs (Garland Science)
    2.Cellular and biomolecular mechanics and mechanobiology, Editors: Gefen, Amit (Springer)


    Prof. Shamik Sen

    IIT Bombay
    Prof. Shamik Sen joined IIT Bombay in July 2010 as an Assistant Professor in the Department of Biosciences and Bioengineering. Dr. Sen earned a B.E. in Mechanical Engineering from Jadavpur University, Kolkata, and a M. Tech in Mechanical Engineering from IIT Kanpur. He then completed his PhD in Mechanical Engineering from University of Pennsylvania, where he worked in the area of mechanobiology.He is currently working in the area of mechanobiology where he is integrating mechanics and biology for probing stem cell biology and cancer cell biology. He is combining experiments with simulations for addressing his research questions.


    The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
    The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
    Date and Time of Exams: 18 December,2020 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
    Registration url: Announcements will be made when the registration form is open for registrations.
    The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
    Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.


    Average assignment score = 25% of average of best 6 assignments out of the total 8 assignments given in the course.
    Exam score = 75% of the proctored certification exam score out of 100

    Final score = Average assignment score + Exam score

    YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.

    Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Bombay.It will be e-verifiable at nptel.ac.in/noc.

    Only the e-certificate will be made available. Hard copies will not be dispatched.

    Once again, thanks for your interest in our online courses and certification. Happy learning.

    - NPTEL team