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Stereochemistry

By Prof.Amit Basak   |   IIT Kharagpur
Learners enrolled: 2071
Stereochemistry of molecules dictates isomerism, chemical and biochemical reactivity. Reactivity. These days, chiral drugs have become an integral part of pharmaceutical industry. A basic concept on 3D structures and conformations of molecules and asymmetric synthesis and other stereochemical principles and attributes are essential. This course will lay the foundation on to which further advanced topics can be built up.

INTENDED AUDIENCE: Chemistry, Biotechnology, Bioscience and Pharmacy.

PRE-REQUISITES:        +12 Chemistry

INDUSTRY SUPPORT:  Pharmaceutical industries, Perfumery Industries                
Summary
Course Status : Completed
Course Type : Core
Duration : 8 weeks
Start Date : 29 Jul 2019
End Date : 20 Sep 2019
Exam Date : 29 Sep 2019 IST
Category :
  • Chemistry
Credit Points : 2
Level : Undergraduate

Page Visits



Course layout

Week 1: Constitution and Configuration; Chemistry in 3D space Chirality and its origin, symmetry criterion; 
Week 2: Stereogenicity and topicity; Enantiomers, Diastereomers, Epimers, Anomers, Atropisomers
Week 3: Nomenclature: Absolute (R/S and D,L) and relative configurations (Threo/erythro , syn/anti and like/unlike)
Week 4: Prochirality, pro-R and pro-S designations; related problems
Week 5: Conformations of acyclic systems: X-CH2-CH2-X and of cyclic systems: cyclopropane, cyclobutane, cyclopentane
Week 6: Conformations of cyclohexane (including mono and disubstituted), cis and trans-decalins
Week 7: Stereoelectronic and steric principles in reactions: Substitution, elimination and addition; selectivity and specificity
Week 8: Stereoelectronic and steric principles in reactions: Substitution, elimination and addition; selectivity and specificity (contd);
               Importance of stereochemistry in real life: some examples

Books and references

1. Stereochemistry by Eliel
2. Stereochemistry by Nasipuri
3. Organic Chemistry by Clayden et. al.

Instructor bio



Prof. Amit Basak
offering this course at the first year level at IIT Kharagpur for many years. Before that, I had taught UG students of Presidency University for more than 10 years. Due to my interaction with Sir Prof J. Baldwin (my PhD supervisor at Oxford) and Prof Talapatra ( PhD supervisor, both of whom are renowned stereochemists, my interest in teaching stereochemistry at UG and PG level grew up immensely.

Course certificate

  • The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centers.
  • The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
  • Date and Time of Exams: 29th September 2019, Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
  • Registration url: Announcements will be made when the registration form is open for registrations.
  • The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
  • Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE
  • Average assignment score = 25% of average of best 6 assignments out of the total 8 assignments given in the course.
  • Exam score = 75% of the proctored certification exam score out of 100
  • Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75
  • If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.
  • Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Kharagpur. It will be e-verifiable at nptel.ac.in/noc.
  • Only the e-certificate will be made available. Hard copies are being discontinued from July 2019 semester and will not be dispatched.


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