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Organic Chemistry in Biology and Drug Development

By Prof. Amit Basak   |   IIT Kharagpur
In the biosphere, the chemistry must be considered in the context of the cell, or an organ, or even a whole organism. That makes mimicking of biological processes to be extremely challenging as the reaction needs to be performed with perfect orthogonality to other functional entities present in a biological system. Today, with the advancement of various spectroscopic and molecular biology techniques and with a better understanding of chemical principles, functions of various bio molecules have been unravelled which has paved the way for development of newer drugs. The present course is an attempt to bridge the gap in our understanding of biological systems and processes at the molecular and functional level. The course first introduces the various kinds of bio molecules, macro to medium size to small, their structures and functions followed by molecular engineering to manipulate their activity and biosynthesis. That creates a perfect platform for the next module on drug design and discovery

INTENDED AUDIENCE   :  Chemistry, Biochemistry, Chemical Biology, Pharmacy Students/faculty
PREREQUISITES     :  Basic Organic Chemistry

Learners enrolled: 1432

SUMMARY

Course Status : Completed
Course Type : Elective
Duration : 12 weeks
Start Date : 29 Jul 2019
End Date : 18 Oct 2019
Exam Date : 16 Nov 2019
Category :
  • Chemistry
  • Level : Postgraduate
    This is an AICTE approved FDP course

    COURSE LAYOUT

    Week 1 : Introduction,Amino Acids,Peptides and proteins
    Week 2 : Peptides and proteins (contd.)
    Week 3 : Peptides and proteins (contd.)
    Week 4 : Proteins as biological catalyst,Concept of inhibition
    Week 5 : Nucleic acids,
    Week 6 : Metabolism,Synthetic biology,Molecular Biology
    Week 7 : Chemistry of cofactors/coenzymes
    Week 8 : Principle of drug design,Modern day drug discovery
    Week 9 : Chemistry of diseases and Drug development
    Week 10: Chemistry of diseases and Drug development (contd.)
    Week 11: Proton pump inhibitors,Gene replacement and delivery
    Week 12: Revision and Problem solving

    BOOKS AND REFERENCES

    Biochemistry by Voet and Voet
    Drug Design by R. Silverman
    Medicinal Chemistry by G. L. Patrick

    INSTRUCTOR BIO



    Prof. Amit Basak
    Offering this course at the first year PG level at IIT Kharagpur for many years. Before that, I had taught UG students of Presidency College (now University) for more than 10 years. Due to my interaction with Sir Prof J. E. Baldwin (my PhD supervisor at Oxford), an extraordinary chemical biologist and Prof S. K. Talapatra (PhD supervisor), renowned stereo chemists, my interest in teaching subjects at the interface of chemistry and biology  PG level grew immensely

    COURSE CERTIFICATE


    • The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
    • The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
    • Date and Time of Exams: 16 November 2019, Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
    • Registration url: Announcements will be made when the registration form is open for registrations.
    • The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
    • Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

    CRITERIA TO GET A CERTIFICATE
    • Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course. 
    • Exam score = 75% of the proctored certification exam score out of 100
    • Final score = Average assignment score + Exam score

    YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75
    • If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.
    • Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT  Kharagpur. It will be e-verifiable at nptel.ac.in/noc.
    • Only the e-certificate will be made available. Hard copies are being discontinued from July 2019 semester and will not be dispatched


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