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Courses » Metal Mediated Synthesis I

Metal Mediated Synthesis I

ABOUT THE COURSE:

The course covers an advance level of organometallic chemistry. Recent development of cross coupling reactions and their applications in organic synthesis, starting from small molecule to naturally and pharmaceutically important compounds, has been described in the prescribed course. In this course, a brief overview about the carbine chemistry and oxidative cyclization is also portrayed.

INTENDED AUDIENCE:
Students, PhD scholars, teachers, industry

CORE/ELECTIVE: Core

PREREQUISITES: Advance Organic and Inorganic Chemistryl

INDUSTRY SUPPORT: All Pharmaceutical Industries

285 students have enrolled already!!

ABOUT THE INSTRUCTOR:



Prof. Debabrata Maiti has done BSc (Chemistry), MSc (Chemistry, IIT B) and received his Ph.D. from Johns Hopkins University (USA) in 2008. After postdoctoral studies at Massachusetts Institute of Technology (MIT), he joined the Department of Chemistry at IIT Bombay in 2011. His research and teaching interests include organometallic chemistry, the development of new and sustainable synthetic methodologies and mechanistic insight.

COURSE LAYOUT:

Week 1 :

Lecture 1:  Assymetric Hydrogenation
Lecture 2:  Transition metal carbenes,Fischer and Schrock carbenes
Lecture 3:  Olefin metathesis
Lecture 4:  Alkyne metathesis
Lecture 5:  Cyclopropanation reaction

Week 2

Lecture 6:  Catalytic cyclopropanation reaction,Introduction to cross coupling reaction
Lecture 7:  Kumada Coupling reaction
Lecture 8:  Suzuki coupling reaction
Lecture 9:  Stille coupling reaction
Lecture 10:Assymetric Suzuki coupling reaction

Week 3

Lecture 11: Sonogashira coupling reaction
Lecture 12: Heck coupling reaction
Lecture 13: Assymetric Heck reaction,Introduction to Buchwald-Hartwig coupling reaction
Lecture 14: Buchwald-Hartwig coupling reaction
Lecture 15: Role of Ligands  its influence in Buchwald-Hartwig coupling reaction


Week 4

Lecture 16: Oxidative cyclization process
Lecture 17: Application of oxidative cyclization in natural product synthesis
Lecture 18: Synthesis of reactive metallacycle intermediate via-Beta-abstraction and their applications
Lecture 19: Kulinkovich Reaction and its mechanism
Lecture 20: Pauson–Khand reaction 

SUGGESTED READING MATERIALS:

Organometallic Chemistry by Gupta, BD and Elias AJ,Hartwig JF,Crabtree RH,Elschenbroich and Salzer,Robin Whyman.
   
CERTIFICATION EXAM :
  • The exam is optional for a fee.
  • Date of Exam: March 31st 2019 (Sunday).
  • Time of Exam: Morning session 9am to 2 noon; Afternoon session: 2pm to 5pm
  • Registration url: Announcements will be made when the registration form is open for registrations.
  • The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published.
CERTIFICATION:

  • Final score will be calculated as : 25% assignment score + 75% final exam score
  • 25% assignment score is calculated as 25% of average of  Best 3 out of 4 assignments
  • E-Certificate will be given to those who register and write the exam and score greater than or equal to 40% final score. Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Bombay. It will be e-verifiable at nptel.ac.in/noc.