The course covers an advance level of organometallic chemistry. Recent development of cross coupling reactions and their applications in organic synthesis, starting from small molecule to naturally and pharmaceutically important compounds, has been described in the prescribed course. In this course, a brief overview about the carbine chemistry and oxidative cyclization is also portrayed.
INTENDED AUDIENCE: Students, PhD scholars, teachers, industry
PREREQUISITES: Advance Organic and Inorganic Chemistryl
INDUSTRY SUPPORT: All Pharmaceutical Industries
285 students have enrolled already!!
ABOUT THE INSTRUCTOR:
Prof. Debabrata Maiti has done BSc (Chemistry), MSc (Chemistry, IIT B) and received his Ph.D. from Johns Hopkins University (USA) in 2008. After postdoctoral studies at Massachusetts Institute of Technology (MIT), he joined the Department of Chemistry at IIT Bombay in 2011. His research and teaching interests include organometallic chemistry, the development of new and sustainable synthetic methodologies and mechanistic insight.
Lecture 11: Sonogashira coupling reaction Lecture 12: Heck coupling reaction Lecture 13: Assymetric Heck reaction,Introduction to Buchwald-Hartwig coupling reaction Lecture 14: Buchwald-Hartwig coupling reaction Lecture 15: Role of Ligands its influence in Buchwald-Hartwig coupling reaction
Week 4 :
Lecture 16: Oxidative cyclization process Lecture 17: Application of oxidative cyclization in natural product synthesis Lecture 18: Synthesis of reactive metallacycle intermediate via-Beta-abstraction and their applications Lecture 19: Kulinkovich Reaction and its mechanism Lecture 20: Pauson–Khand reaction
SUGGESTED READING MATERIALS:
Organometallic Chemistry by Gupta, BD and Elias AJ,Hartwig JF,Crabtree RH,Elschenbroich and Salzer,Robin Whyman.
CERTIFICATION EXAM :
The exam is optional for a fee.
Date of Exam: March 31st 2019 (Sunday).
Time of Exam: Morning session 9am to 2 noon; Afternoon session: 2pm to 5pm
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published.
Final score will be calculated as : 25% assignment score + 75% final exam score
25% assignment score is calculated as 25% of average of Best 3 out of 4 assignments
E-Certificate will be given to those who register and write the exam and score greater than or equal to 40% final score. Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Bombay. It will be e-verifiable at nptel.ac.in/noc.