Drug Delivery: Principles and Engineering

By Prof. Rachit Agarwal   |   IISc Bangalore
Learners enrolled: 2540
This course introduces concepts of drug delivery to meet medical challenges. The course is designed to be modular, with each module focusing on the various aspects of drug delivery.

INTENDED AUDIENCE : Anyone in bachelors having completed two year
PREREQUISITES : None. A course in biochemistry, molecular biology, anatomy is recommended
INDUSTRY SUPPORT : All pharmaceuticals, hospitals and biotechnology industries
Course Status : Completed
Course Type : Elective
Duration : 12 weeks
Start Date : 29 Jul 2019
End Date : 18 Oct 2019
Exam Date : 16 Nov 2019 IST
Category :
  • Biological Sciences & Bioengineering
Credit Points : 3
Level : Undergraduate

Page Visits

Course layout

Week 1 : Pharmacokinetics: Bioavailability, Elimination, Therapeutic index
Week 2 : Prodrugs, Controlled release
Week 3 : Polymers: Synthesis, properties, characterization, crystallinity and amorphousness 
Week 4 : Biopolymers: Natural and Synthetic, biocompatibility, Biodegradation, commonly used biopolymers
Week 5 : Polymer-Drug conjugates, PEGylation
Week 6 : Diffusion controlled systems, Ficks laws, Reservoir systems, Non-erodible matrix systems, Bio-erodible Systems
Week 7 : Hydrogels: Physical or chemical, pore-size calculation, in-situ crosslinking
Week 8 : Nano and Micro-particles: Dendrimers, Liposomes, Micelles 
Week 9 : Metal and polymeric particles, effect of particle shape, charge and elasticity
Week 10: Protein Adsorption and tissue engineering, Drug delivery in tissue engineering
Week 11: Implant associated infections, Route specific delivery: Oral, Subcutaneous, Intramuscular, transdermal, inhalation, intravenous
Week 12: Vaccines, Cancer vaccines, Cell and gene delivery, Smart responsive drug delivery, Targeted drug delivery, Nanotoxicology and market translation 

Books and references

1.Drug Delivery: Engineering Principles for Drug Therapy, W. Mark Saltzman, Oxford University Press, 2001
2.Drug Delivery: Fundamentals and Applications, Anya M. Hillery and Kinam Park, 2nd Edition, CRC Press, 2016

Instructor bio

Rachit Agarwa
  • Employment .Assistant Professor June 2017 – present Centre for Biosystems Science and Engineering, Indian Institute of Science, Bangalore .
  • Post-doctoral Fellow August 2013 – May 2017 Andres J. Garcia, Georgia Institute of Technology, Atlanta, Georgia, USA 
Education .
  • Ph.D. Biomedical Engineering May 2013 University of Texas at Austin, Texas, USA; Dissertation title: Effect of shape on cell internalization of polymeric hydrogel nanoparticles.
  • Doctoral portfolio program in Nanoscience and Nanotechnology May 2013 University of Texas at Austin, Texas, USA .
  • B.Tech and M.Tech (combined degree) - Biotechnology and Biochemical Engineering June 2009 Indian Institute of Technology, Kharagpur, India; Thesis Title: Crystallization and Enzyme Assay of GAPDH from TASAR Silk Worm

Course certificate

  • The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
  • The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
  • Date and Time of Exams: 16 November 2019, Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
  • Registration url: Announcements will be made when the registration form is open for registrations.
  • The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
  • Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

  • Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course. 
  • Exam score = 75% of the proctored certification exam score out of 100
  • Final score = Average assignment score + Exam score

  • If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.
  • Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IISc Bangalore. It will be e-verifiable at nptel.ac.in/noc.
  • Only the e-certificate will be made available. Hard copies are being discontinued from July 2019 semester and will not be dispatched

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