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Courses » Principles and Applications of NMR Spectroscopy

Principles and Applications of NMR Spectroscopy

ABOUT THE COURSE
The objective of the course is to teach the basic aspects of nuclear magnetic resonance (NMR) spectroscopy, which is an important analytical tool in chemical and pharmaceutial industry for structural characterization of molecules.
The topics to be covered will include one-dimensional NMR, Chemical shifts, J-coupling, Interpretation of 1D NMR spectrum, Basics of 2D NMR, Different 2D NMR experiments and their application/interpretation, Application of 2D NMR for assignment of molecules and peptides. 

INTENDED AUDIENCE
Students of M. Sc and Ph. D

PRE-REQUISITES 
Should have studied Chemistry at undergraduate level and Mathematics at least up to 12th Standard

INDUSTRY SUPPORT – LIST OF COMPANIES/INDUSTRY THAT WILL RECOGNIZE/VALUE THIS ONLINE COURSE
All pharmaceutical companies (e.g., Reddy's laboratories, CIPLA, Sun Pharma) and R &D laboratories like Hindustan Unilever, Biotech companies (Biocon)

COURSE INSTRUCTOR


Prof. H. S. Atreya is an Associate Professor at the Indian Institute of Science. He has nearly 20 years of experience in the area of NMR spectroscopy. He has authored approximately 75 peer review publications, edited one book and has two US patents. Research interests include development and application of new  magnetic resonance methodologies for studying structure, function and dynamics of biomolecules.

COURSE LAYOUT

Week 1: 
Introduction to NMR spectroscopy

Week 2: 
Chemical shifts and J-coupling

Week 3: 
One-dimensional proton NMR

Week 4: 
One dimensional NMR of X-nuclei (13C, 15N, 31P and 19F)

Week 5: 
Homonuclear 2D NMR

Week 6: 
Heteronucler 2D NMR

Week 7: 
Structure determination of molecules

Week 8: 
Advanced topics (Solvent suppression, Drug Discovery, DOSY)

SUGGESTED READING

1. Basic One and Two Dimensional NMR: by Horst Fiebrolin

2. NMR Spectroscopy Explained: by Neil Jacobsen 
3.Understanding NMR spectroscopy: by James Keeler 
4. Introduction to Spectroscopy: by Pavia et al.

CERTIFICATION EXAM :
  • The exam is optional for a fee.
  • Date and Time of Exams: April 28 (Saturday) and April 29 (Sunday) : Morning session 9am to 12 noon; 
  • Exam for this course will be available in one session on both 28 and 29 April.
  • Registration url: Announcements will be made when the registration form is open for registrations.
  • The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published.

CERTIFICATION:

  • Final score will be calculated as : 25% assignment score + 75% final exam score
  • 25% assignment score is calculated as 25% of average of  Best 6 out of 8 assignments
  • E-Certificate will be given to those who register and write the exam and score greater than or equal to 40% final score. Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IISc. It will be e-verifiable at nptel.ac.in/noc.