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Courses » Human Molecular Genetics

Human Molecular Genetics

ABOUT THE COURSE:

This is an introductory course designed primarily for students in the undergraduate or master’s programs interested in biomedical research, genetic counseling, medicine, and clinical genetics. This course is expected introduce the rapid advancements in our understanding the role of human genome in health and disease. We would introduce key concepts of inheritance of human traits, pedigree analysis, and chromosome organization. Molecular biology tools used for understanding the genome, gene structure and gene mutations, gene mapping and gene cloning strategies will also be covered. Objectives and outcome of human genome project and the HapMap project will also be discussed at the end.

INTENDED AUDIENCE:
  • Students interested in pursuing research in human molecular genetics.
  • Medical students and practicing clinicians interested in understanding the principles and complexities of human genetics.
  • Students interested in careers in genetic counselling and DNA diagnostics.
  • Scientists working in public health service, counselling centres, and diagnostic laboratories. 

CORE/ELECTIVE: Elective

UG/PG: Both UG/PG

PREREQUISITES: Participants are expected to have at least class 12 level understanding in genetics.

INDUSTRY SUPPORT: Medical and pharma companies, paramedic clinical centers, educational institutes, and hospitals.

ABOUT THE INSTRUCTOR:



Prof. S. Ganesh teaches biology, genetics and human molecular genetics at IIT Kanpur. His research interests include human molecular genetics and neuroscience. He works on genetic forms of neurodegenerative disorders in humans to understand their genetics and disease mechanisms, and to develop therapeutics. For details see: http://home.iitk.ac.in/~sganesh/

COURSE LAYOUT:

Week 1  : Fundamentals of central dogma (DNA, RNA and proteins; mutations), Chromosome structure and function (organization; structure-function relationship; chromosome abnormalities).
Week 2  : Genes in pedigree (Mendelian pedigree patterns, complications to pedigree patterns), DNA cloning and hybridization techniques (vector based cloning; nuclei acid hybridizations; PCR-based DNA analyses)
Week 3  : Mutation and instability of human DNA (mutation and polymorphism; pathogenic mutations, repeat expansions), Molecular pathology (types of mutations; animal models for human disease)
Week 4  : Identifying human disease genes (functional cloning versus positional cloning; mutation screening), Complex diseases; The Human Genome and HapMap projects

SUGGESTED READING MATERIALS:

•    Human Molecular Genetics 4 Tom Strachan, Andrew P. Read Garland Science/Taylor & Francis Group, 2011
CERTIFICATION EXAM :
  • The exam is optional for a fee.
  • Date and Time of Exams: April 28 (Saturday) and April 29 (Sunday) :  Afternoon session: 2pm to 5pm
  • Registration url: Announcements will be made when the registration form is open for registrations.
  • The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published.

CERTIFICATION:

  • Final score will be calculated as : 25% assignment score + 75% final exam score
  • 25% assignment score is calculated as 25% of average of  Best 3 out of 4 assignments
  • E-Certificate will be given to those who register and write the exam and score greater than or equal to 40% final score. Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Kanpur. It will be e-verifiable at nptel.ac.in/noc.