Courses » Aspects of Biochemical Engineering

Aspects of Biochemical Engineering

Biochemical Reaction Engineering is mostly deals with the most complicated life systems as compared to Chemical Reaction Engineering. To describe the behavior of any life system in terms of mathematical form is the basic essence of biochemical reaction engineering. The present course in true sense is an interdisciplinary subject since biologist, physicist, chemist, technologist and mathematician all join hand in hand to develop realistic models. This specialized subject comprises of transport processes, sophisticated advanced control system besides conventional biology, physics and mathematics. Production of biomolecules can be done broadly in two different ways namely, using enzymes and microbial cells. The present course is designed to cater all the above aspects of the subject. Students undergoing this course will be initially able to differentiate between conventional chemical reaction engineering and biochemical reaction engineering. They also develop the expertise to do the design of any biochemical process which will be very much useful for the industries.

  • Biotechnology
  • Chemical Engineering
  • Biochemical Engineering
  • Environmental Engineering
  • Biochemistry
  • Mathematics in 10+2



  • IFB Agro Industry; IOC; ONGC
  • Dr. Reddy’s Laboratories
  • Biocon
  • United Beverages
  • Ranbaxy Lab. Ltd.
  • Phizer India. 

542 students have enrolled already!!


Debabrata Das pursued his doctoral studies from Indian Institute of Technology (IIT) Delhi. He is a Senior Professor at IIT Kharagpur. He was also associated as MNRE Renewable Energy Chair Professor. He has pioneered the promising R&D of Bioenergy production processes by applying fermentation technology. Prof. Das is involved in three different area of research: Gaseous energy recovery from organic wastes; algal biorefinery and CO2 sequestration; and microbial fuel cell.  He is presently involved in teaching both undergraduate and post-graduate courses on Biochemical Reaction Engineering; Aspects of Biochemical Engineering; Bioprocess Plant and Equipment Design; and Bioprocess Technology for the students of Department of Biotechnology; Department of Chemical Engineering; Department of Chemistry and School Energy Science and Engineering. He has been teaching for the last 29 years. He was associated as a Biochemical Engineer in M/s. Citurgia Biochemicals Ltd., Surat and involved in citric acid production through fermentation process. Presently, he has the Google h-index of 43 for his research work. He has about 137 research publications in the peer reviewed journals and contributed more than 30 chapters in the books published by International publishers. He is the author of the books: “Biohydrogen Production: Fundamentals and Technology Advances” published by M/s. CRC Press, New York and “Biohythane: Fuel for the future” published by Pan Stanford Publishing, Singapore. He is the Editor of the books entitled “Algal Biorefinery: An Integrated Approach”  and “A bioelectrochemical system that convert wastes to Watts” published separately by Springer, Switzerland and Capital Publishing Company, India. He has two Indian patents. Presently, he was involved in design, fabrication,and commission 10 m3 biohydrogen pilot plant at Indian Institute of Technology Kharagpur. He was awarded IAHE Akira Mitsue award 2008 and BRSI Malaviya Memmorial award 2013 for his contribution in hydrogen research. He is the Editor-in-Chief of American Journal of Biomass and Bioenergy. He is the member of the editorial board of several International Journals. He is the Fellow of International Association for Hydrogen Energy (IAHE), Indian National Academy of Engineering (INAE); Biotechnology Research Society of India (BRSI); West Bengal Academy of Science and Technology (WAScT); and Institution of Engineers (IE).


Week 1: Microbiology, Biochemistry and Bioproducts

Week 2: Stoichiometry and Thermodynamics of biochemical reactions
Week 3: Kinetics of homogeneous chemical reactions

Week 4: Different types of bioreactors and reactor analysis

Week 5: Kinetics of enzyme catalyzed reactions using free enzymes

Week 6: Kinetics of enzyme catalyzed reactions using immobilized enzymes

Week 7: Kinetics of substrate utilization, product formation and biomass production of microbial cells

Week 8: Kinetics of substrate utilization, product formation and biomass production of microbial cells

Week 9: Design and analysis of activated sludge process and anaerobic digester. Scale up of bioreactor

Week 10:Transport phenomenon in bioprocess

Week 11:Air and medium sterilization

Week 12:Operation and Process control, Downstream processing, Economic analysis of biochemical processes and summary & conclusion


1. Chemical Reaction Engineering, Octave Levenspiel
2. Biochemical Engineering Fundamentals by Bailey and Ollis
3. Bioprocess Engineering Principles by Doran
4. Bioprocess Engineering Basic Concepts by Shular and Kargi
5. Biochemical Engineering by Blanch and Clark
6. Biochemical Engineering by Aiba, Humphrey and Millis

  • The exam is optional for a fee. · 
  • Date and Time of Exams: April 28 (Saturday) and April 29 (Sunday) :
    Afternoon session: 2pm to 5pm.
  • Registration url: Announcements will be made when the registration form is open for registrations.  
  • The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. 

  • Final score will be calculated as : 25% assignment score + 75% final exam score  
  • 25% assignment score is calculated as 25% of average of 12 weeks course: Best 8 out of 12 assignments  
  • E-Certificate will be given to those who register and write the exam and score greater than or equal to 40% final score. Certificate will have your name, photograph and the score in the final exam with the breakup. It will have the logos of NPTEL and IIT Kharagpur. It will be e-verifiable at nptel.ac.in/noc.