Courses » Human Molecular Genetics

Human Molecular Genetics

About the course
This is an introductory course designed primarily for students in the undergraduate or master’s programs interested in biomedical research, genetic counseling, medicine, and clinical genetics. This course is expected introduce the rapid advancements in our understanding the role of human genome in health and disease. We would introduce key concepts of inheritance of human traits, pedigree analysis, and chromosome organization. Molecular biology tools used for understanding the genome, gene structure and gene mutations, gene mapping and gene cloning strategies will also be covered. Objectives and outcome of human genome project and the HapMap project will also be discussed at the end. 

Intended Audience

  • Students interested in pursuing research in human molecular genetics.
  • Medical students and practicing clinicians interested in understanding the principles and complexities of human genetics.
  • Students interested in careers in genetic counselling and DNA diagnostics.
  • Scientists working in public health service, counselling centres, and diagnostic laboratories. 

Participants are expected to have at least class 12 level understanding in genetics. 

Industries that will recognize this course
Medical and pharma companies, paramedic clinical centers, educational institutes, and hospitals.

Course instructor

Prof. S. Ganesh teaches biology, genetics and human molecular genetics at IIT Kanpur. His research interests include human molecular genetics and neuroscience. He works on genetic forms of neurodegenerative disorders in humans to understand their genetics and disease mechanisms, and to develop therapeutics. 

For details see: http://home.iitk.ac.in/~sganesh/

Course layout

Week 1:
 [2 hrs; 4 x 30 min]

Fundamentals of central dogma (DNA, RNA and proteins; mutations)
Chromosome structure and function (organization; structure-function relationship; chromosome abnormalities).

Week 2:
 [3 hrs; 6 x 30 min]

Genes in pedigree (Mendelian pedigree patterns, complications to pedigree patterns)
DNA cloning and hybridization techniques (vector based cloning; nuclei acid hybridizations; PCR-based DNA analyses)

Week 3: [2 hrs: 6 x 20 min]

Mutation and instability of human DNA (mutation and polymorphism; pathogenic mutations, repeat expansions)
Molecular pathology (types of mutations; animal models for human disease)

Week 4: [3 hrs: 6 x 20 min]

Identifying human disease genes (functional cloning versus positional cloning; mutation screening)
Complex diseases; The Human Genome and HapMap projects

Suggested Reading

Human Molecular Genetics 4 Tom Strachan, Andrew P. Read Garland Science/Taylor & Francis Group, 2011

More details about the course

Course url: https://onlinecourses.nptel.ac.in/noc17_bt01
Course duration: 4 weeks
Start date and end date of course: 23 January 2017-17 February 2017
Date of exam: 26 March, 2017
Time of exam: Shift 1: 9am-12noon; Shift 2: 2pm-5pm
Any one shift can be chosen to write the exam for a course

Final List of exam cities will be available in exam registration form.
Registration url - Announcements will be made when the registration form is open for registrations.
Exam Fee: The online registration form has to be filled and the certification exam fee of approximately Rs 1000 needs to be paid.


E-Certificate will be given to those who register and write the exam and score greater than or equal to 40% final score. 

Final score = 25% assignment score + 75% exam score
25% assignment score is calculated as 25% of average of scores of Best 3 out of 4 assignments

Certificate will have your name, photograph and the score in the final exam with the breakup. It will have the logos of NPTEL and IIT Kanpur. It will be e-verifiable at nptel.ac.in/noc.